For public regions, I don’t think so. At worst, there might be a tiny bit of extra latency as the orchestrator works across datacenters. But region is also used

For public regions, I don’t think so. At worst, there might be a tiny bit of extra latency as the orchestrator works across datacenters. But region is also used by Azure Stack and the rules might be different then. I worked on this a number of years ago and if you are really concerned, you should ask support.