> About 98% of intelligence-affecting alleles are in non-protein-coding regions. The remaining 2% of variants are in protein-coding regions and are probably not

> About 98% of intelligence-affecting alleles are in non-protein-coding regions. The remaining 2% of variants are in protein-coding regions and are probably not safe to target with current editing tools due to the risk of frameshift mutations. Non-coding variants may not be safe to modify either. Genes likely function as partially overlapping sets with varying effects in different environments. That's why even monogenic disease causing variants have different levels of penetrance, age of onset, etc... I think we'll need a lot of individual and population level research done in animals and humans before we can safely and effectively modify sets of variants to achieve certain outcome/s.