I believe we might be at the point where supply chain security (and code base security) might warrant the question why you cant implement something on an M0+.

I believe we might be at the point where supply chain security (and code base security) might warrant the question why you cant implement something on an M0+. If you really need higher speeds for reaction time, use an ASIC or FPGA. We already do this with USB3 or Ethernet controllers.