While the gap has closed over the years, with high quality web apps and the ability of the browser to send you notifications, I still prefer to use Thunderbird

While the gap has closed over the years, with high quality web apps and the ability of the browser to send you notifications, I still prefer to use Thunderbird to check my multiple accounts, and only notify for my primary folder, while lots of relative junk gets filtered down to sub-folders, where I do not want notifications.