I am well aware of these approaches, having worked on some of them myself in prior work I've done. You always run into limitations of what was known about the b

I am well aware of these approaches, having worked on some of them myself in prior work I've done. You always run into limitations of what was known about the biology and how various things interact. The network models will probably work some day, but my point above was that this will only happen after a lot of hard wet bench work happens. There's just too much we don't know right now to use these techniques to develop deep understanding. Sometimes, when we were lucky, they would support an existing hypothesis. But that was only for activity in a single cancer cell line in a specific experiment, not a whole organism which is what matters for a drug.