Over-hyped? In my neck of the woods these approaches are treated with extreme skepticism for just the reasons you mention. For instance: De novo protein foldin

Over-hyped? In my neck of the woods these approaches are treated with extreme skepticism for just the reasons you mention. For instance: De novo protein folding is not a solved problem, so how can a simulation predict dynamics for a protein whose conformation isn't even known? I'm sure in the year 2150 when my grandchildren go to the doctor to be scanned by the tricorder, the results will go to the full-cell (and full-body) simulator...but for now, I think bioinformatics is better served by sticking to higher levels of abstraction like transcript and protein counts (for disease modeling purposes).