Exactly my thought. It's often reported that the antidepressant effect came from the increased ability to look at your problems from a new perspective. If this

Exactly my thought. It's often reported that the antidepressant effect came from the increased ability to look at your problems from a new perspective. If this new perspective isn't experienced, it seems highly unlikely this would work. Thinking about the mechanism of classic anti-depressants like SSRIs, you expect a boosted effect of the happy chemicals to make people more happy. With anything that is few or single-dose you expect changes in thought and behavior patterns to have the antidepressant effect. These lasting changes must come from something that is not happy chemicals, but a new perspective on life.