If looks are a top priority, web pages seem pretty hard to beat. They also give built in separation of frontend and backend, and the option of remote access sh

If looks are a top priority, web pages seem pretty hard to beat. They also give built in separation of frontend and backend, and the option of remote access should you later need it. Plus, you can use them just like a native app: Just make a tiny minimal tkinter or similar kind of GUI, that just has an "Open browser UI" button. You can even secure it against daemons running as other users on the same machine, by having the launch button put a token in the URL, but I haven't seen this done anywhere.