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There are concerning risks: https://en.wikipedia.org/wiki/Hallucinogen_persisting_perception_disorder https://en.wikipedia.org/wiki/Hallucinogen_persisting_perc

There are concerning risks: https://en.wikipedia.org/wiki/Hallucinogen_persisting_perception_disorder https://en.wikipedia.org/wiki/Hallucinogen_persisting_percep... How does the paper address this? Haven't checked. [EDIT] Ctrl+f on "HPPD" and "disorder" found nothing relevant.

zoklet-enjoyer 3y ago
I doubt the number of people experiencing this is anywhere close to what Wikipedia says it is. I know a lot of people who have used a lot of psychedelics from their late teens to 30s/40s and none of them have had HPPD
- schmichael 3y ago
  Only one of the studies Wikipedia included had concerning results, and it was a survey of users. Such studies are good indicators of where future research should be done, but only demonstrate a loose correlation between psychedelics and HPPD. There’s no differentiating users who are “self-medicating” the issue from psychedelics causing the issue.
- lambdaba 3y ago
  AFAIK this is not something that's seen with psilocybin, maybe with frequent high dose LSD... Anyway, I wish people didn't even bring this up because it'd be a shame if that dissuaded anyone to try psilocybin.
schmichael 3y ago
While I do hope these issues are researched, I’m not sure why you find them “concerning.” According to Wikipedia only 1 of the 2 studies really seems well done, and that one reported no HPPD. Since SSRIs are extremely widely prescribed already and seem capable of causing HPPD as well, I’m not sure what’s making you find them concerning for psilocybin in particular.
deleted 3y ago
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tpm 3y ago
That's mostly a risk for recreational users I'd say. Anecdotally, from people with psychedelic experience I know, only massive multidrug abusers experience this sort of issues.
deepnotderp 3y ago
Most HPPD is just floaters or tracers, and SSRIs can cause them too. The magnitude of HPPD and the frequency/prevalence need to be studied, but I think seeing some extra floaters in exchange for having a will to live is a trade most would take.
- gafage 3y ago
  Not all depression is "I have no will to live".
  - dkjaudyeqooe 3y ago
    No, but the one that does take away your will to live is the one you most want to treat.
zug_zug 3y ago
It addresses it as such "Visual perceptual effects (assessed following resolution of acute drug effects) were reported by 22/50 (44%) psilocybin participants on the day of dosing and by 3/50 (6%) after the dosing day, all resolved by study conclusion (See Table 3 for details)." [table shows it resolved by day 9] However the study also shows 2 people in the experiment group (1 in the control) had an adverse effect that required psychiatric attention. Unclear what that means (admitted to a hospital or a phonecall with the therapist?)
VHRanger 3y ago
I mean even "bad trips" are an important concern? Anecdotally I've had good experiences with psilocybin, but a bad trip induced a 6month long depression in a friend of mine.

zoklet-enjoyer 3y ago

I doubt the number of people experiencing this is anywhere close to what Wikipedia says it is. I know a lot of people who have used a lot of psychedelics from their late teens to 30s/40s and none of them have had HPPD

schmichael 3y ago
Only one of the studies Wikipedia included had concerning results, and it was a survey of users. Such studies are good indicators of where future research should be done, but only demonstrate a loose correlation between psychedelics and HPPD. There’s no differentiating users who are “self-medicating” the issue from psychedelics causing the issue.
lambdaba 3y ago
AFAIK this is not something that's seen with psilocybin, maybe with frequent high dose LSD... Anyway, I wish people didn't even bring this up because it'd be a shame if that dissuaded anyone to try psilocybin.

schmichael 3y ago

While I do hope these issues are researched, I’m not sure why you find them “concerning.” According to Wikipedia only 1 of the 2 studies really seems well done, and that one reported no HPPD. Since SSRIs are extremely widely prescribed already and seem capable of causing HPPD as well, I’m not sure what’s making you find them concerning for psilocybin in particular.

deleted 3y ago

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tpm 3y ago

That's mostly a risk for recreational users I'd say. Anecdotally, from people with psychedelic experience I know, only massive multidrug abusers experience this sort of issues.

deepnotderp 3y ago

Most HPPD is just floaters or tracers, and SSRIs can cause them too. The magnitude of HPPD and the frequency/prevalence need to be studied, but I think seeing some extra floaters in exchange for having a will to live is a trade most would take.

gafage 3y ago
Not all depression is "I have no will to live".
- dkjaudyeqooe 3y ago
  No, but the one that does take away your will to live is the one you most want to treat.

zug_zug 3y ago

It addresses it as such "Visual perceptual effects (assessed following resolution of acute drug effects) were reported by 22/50 (44%) psilocybin participants on the day of dosing and by 3/50 (6%) after the dosing day, all resolved by study conclusion (See Table 3 for details)." [table shows it resolved by day 9] However the study also shows 2 people in the experiment group (1 in the control) had an adverse effect that required psychiatric attention. Unclear what that means (admitted to a hospital or a phonecall with the therapist?)

VHRanger 3y ago

I mean even "bad trips" are an important concern? Anecdotally I've had good experiences with psilocybin, but a bad trip induced a 6month long depression in a friend of mine.