3 ms·

Those are very high doses of each. An average multivitamin has 1.8 mg of B6 (vs. 20 mg in the study) and 6 mcg of B12 (vs. 55 mcg in the study). I am surprised

Those are very high doses of each. An average multivitamin has 1.8 mg of B6 (vs. 20 mg in the study) and 6 mcg of B12 (vs. 55 mcg in the study). I am surprised anyone wants to take that much, but I guess the smokers were trying anything they could (short of actually quitting) to compensate for the effect their habit has on their health.

mthoms 3y ago
Aren’t standalone B12 supplements typically measured in 3-4 digits (mcg)? I’m currently taking 1000mcg daily but I’ve seen up to 2500 at the local pharmacy.
- geeB 3y ago
  Absorption is poor sublingually and is limited by https://en.m.wikipedia.org/wiki/Intrinsic_factor https://en.m.wikipedia.org/wiki/Intrinsic_factor so I wouldn’t be surprised if most of those doses just get destroyed in the stomach
  - mthoms 3y ago
    I have exactly that problem - malabsorption. The sublingual tablets have helped considerably. I’m just trying to understand why the other commenter considers the dose mention as “high”. I’ve never heard that claimed before.
    - _xerces_ 3y ago
      I was referring to multivitamin levels which are typically ~100% RDA, so to get the levels the study considered harmful, you have to be intentionally taking large doses of B Vitamins which is easy not to do.
      - ty4smoking 3y ago
        Some Caffeine Shots include very high doses of B6 and B12 vitamins. ## 2023-12: B6/B12 RDVs, RDV % Supplement Facts inconsistencies 5-Hour Energy nutrition facts: https://www.google.com/search?q=5+hour+energy+nutrition+facts https://www.google.com/search?q=5+hour+energy+nutrition+fact... : > B6: 40mg: 2000% RDV > B12: 500mcg: 8333% RDV 5-Hour Energy Extra Strength: > B6: 40mg: 2353% > B12: 500mcg: 20833% Summit Red Thunder Energy Shot nutrition facts: https://www.google.com/search?q=Summit+Red+Thunder+Energy+Shot+nutrition+facts https://www.google.com/search?q=Summit+Red+Thunder+Energy+Sh... > Kirkland Signature Extra Strength: > B6: 40mg: 2533% RDV > B12: 500mcg: 20833% RDV ... Again, /? b6 b12 male smokers https://www.google.com/search?q=b6+b12+male+smokers https://www.google.com/search?q=b6+b12+male+smokers "Long-Term, High-Dose Vitamin B6/B12 Use Associated With Increased Lung Cancer Risk Among Men" (2023) https://cancer.osu.edu/news/long-term-high-dose-vitamin-b6-b12-use-associated-with-increased-lung-cancer-risk-among-men https://cancer.osu.edu/news/long-term-high-dose-vitamin-b6-b...

mthoms 3y ago

Aren’t standalone B12 supplements typically measured in 3-4 digits (mcg)? I’m currently taking 1000mcg daily but I’ve seen up to 2500 at the local pharmacy.

geeB 3y ago
Absorption is poor sublingually and is limited by https://en.m.wikipedia.org/wiki/Intrinsic_factor https://en.m.wikipedia.org/wiki/Intrinsic_factor so I wouldn’t be surprised if most of those doses just get destroyed in the stomach
- mthoms 3y ago
  I have exactly that problem - malabsorption. The sublingual tablets have helped considerably. I’m just trying to understand why the other commenter considers the dose mention as “high”. I’ve never heard that claimed before.
  - _xerces_ 3y ago
    I was referring to multivitamin levels which are typically ~100% RDA, so to get the levels the study considered harmful, you have to be intentionally taking large doses of B Vitamins which is easy not to do.
    - ty4smoking 3y ago
      Some Caffeine Shots include very high doses of B6 and B12 vitamins. ## 2023-12: B6/B12 RDVs, RDV % Supplement Facts inconsistencies 5-Hour Energy nutrition facts: https://www.google.com/search?q=5+hour+energy+nutrition+facts https://www.google.com/search?q=5+hour+energy+nutrition+fact... : > B6: 40mg: 2000% RDV > B12: 500mcg: 8333% RDV 5-Hour Energy Extra Strength: > B6: 40mg: 2353% > B12: 500mcg: 20833% Summit Red Thunder Energy Shot nutrition facts: https://www.google.com/search?q=Summit+Red+Thunder+Energy+Shot+nutrition+facts https://www.google.com/search?q=Summit+Red+Thunder+Energy+Sh... > Kirkland Signature Extra Strength: > B6: 40mg: 2533% RDV > B12: 500mcg: 20833% RDV ... Again, /? b6 b12 male smokers https://www.google.com/search?q=b6+b12+male+smokers https://www.google.com/search?q=b6+b12+male+smokers "Long-Term, High-Dose Vitamin B6/B12 Use Associated With Increased Lung Cancer Risk Among Men" (2023) https://cancer.osu.edu/news/long-term-high-dose-vitamin-b6-b12-use-associated-with-increased-lung-cancer-risk-among-men https://cancer.osu.edu/news/long-term-high-dose-vitamin-b6-b...