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>and another which results in reduced glucose and fructose content in the potato, That's pretty amazing. Imagine if we can change apples to produce Aspartame i

>and another which results in reduced glucose and fructose content in the potato, That's pretty amazing. Imagine if we can change apples to produce Aspartame instead of sugars!

iwontberude 3y ago
I don’t see how a plant is supposed to metabolize the aspartame for energy?
- maxerickson 3y ago
  It would only be a successful reproductive strategy if some external actor decided to propagate the plants that were putting something not useful to the seeds into the fruit.
hedora 3y ago
Unless you are diabetic, aspartame is much worse for you than sugar. It causes metabolic issues, such as reduced metabolism (leading to more weight gain than a subjectively equivalent amount of sugar), migraines in some people, interacts with drugs, is bad for your digestive tract, and probably has other side effects. Even if you are diabetic, you can already eat apples. They have a low glycemic index.
- liamwire 3y ago
  Extraordinary claims require extraordinary evidence. Can you back any of this up, or provide a reason I should believe what you’re saying? Because it directly contradicts decades of research on what is perhaps the most scrutinised and studied dietary supplement in the world. Aspartame is safe, and very well tolerated. You’re spreading misinformation.
  - willmadden 3y ago
    You are the one spreading misinformation. Aspartame is horrible for you. Here, have a read. I have more if you would like them. https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1003950 https://journals.plos.org/plosmedicine/article?id=10.1371/jo... https://www.sciencedaily.com/releases/2022/03/220324143800.htm https://www.sciencedaily.com/releases/2022/03/220324143800.h... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1392232/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1392232/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1964906/pdf/ehp0115-001293.pdf http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1964906/pdf/ehp0... http://www.mpwhi.com/soffritti_2010_20896_fta.pdf http://www.mpwhi.com/soffritti_2010_20896_fta.pdf https://ehjournal.biomedcentral.com/articles/10.1186/s12940-021-00725-y https://ehjournal.biomedcentral.com/articles/10.1186/s12940-... https://annalsofglobalhealth.org/articles/10.5334/aogh.4163 https://annalsofglobalhealth.org/articles/10.5334/aogh.4163 http://ajcn.nutrition.org/content/96/6/1419.long http://ajcn.nutrition.org/content/96/6/1419.long https://www.ncbi.nlm.nih.gov/pubmed/24436139 https://www.ncbi.nlm.nih.gov/pubmed/24436139 https://www.pnas.org/doi/10.1073/pnas.2213120119 https://www.pnas.org/doi/10.1073/pnas.2213120119 https://news.fsu.edu/news/university-news/2022/12/08/fsu-research-links-common-sweetener-with-anxiety/ https://news.fsu.edu/news/university-news/2022/12/08/fsu-res... https://www.nature.com/articles/s41598-023-41213-2 https://www.nature.com/articles/s41598-023-41213-2 https://www.ncbi.nlm.nih.gov/pubmed/8939194 https://www.ncbi.nlm.nih.gov/pubmed/8939194 https://www.youtube.com/watch?v=yCoBuTr0Or0 https://www.youtube.com/watch?v=yCoBuTr0Or0 http://www.cmaj.ca/content/189/28/E929 http://www.cmaj.ca/content/189/28/E929 https://www.statnews.com/2017/07/17/artificial-sweeteners-weight-loss/ https://www.statnews.com/2017/07/17/artificial-sweeteners-we... https://blogs.wsj.com/experts/2017/09/14/why-one-cardiologist-has-drunk-his-last-diet-soda/ https://blogs.wsj.com/experts/2017/09/14/why-one-cardiologis... https://www.philly.com/philly/health/this-cardiologist-wants-his-family-to-cut-back-on-diet-soda-should-yours-too-20170912.html https://www.philly.com/philly/health/this-cardiologist-wants... https://www.ncbi.nlm.nih.gov/pubmed/27129676 https://www.ncbi.nlm.nih.gov/pubmed/27129676 http://stroke.ahajournals.org/content/early/2017/04/20/STROKEAHA.116.016027 http://stroke.ahajournals.org/content/early/2017/04/20/STROK... https://www.bumc.bu.edu/busm/2017/04/20/daily-consumption-of-sodas-fruit-juices-and-artificially-sweetened-sodas-affect-brain/ https://www.bumc.bu.edu/busm/2017/04/20/daily-consumption-of... https://www.washingtonpost.com/news/morning-mix/wp/2017/04/21/study-links-diet-soda-to-higher-risk-of-stroke-dementia/?utm_term=.2bfedb009058 https://www.washingtonpost.com/news/morning-mix/wp/2017/04/2... https://www.ncbi.nlm.nih.gov/pubmed/24787915 https://www.ncbi.nlm.nih.gov/pubmed/24787915 https://www.ncbi.nlm.nih.gov/pubmed/24787917 https://www.ncbi.nlm.nih.gov/pubmed/24787917 https://www.ncbi.nlm.nih.gov/pubmed/1579221 https://www.ncbi.nlm.nih.gov/pubmed/1579221 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474447/pdf/envhper00434-0053.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474447/pdf/env... https://www.ncbi.nlm.nih.gov/pubmed/28198207 https://www.ncbi.nlm.nih.gov/pubmed/28198207 https://www.ncbi.nlm.nih.gov/pubmed/28049023 https://www.ncbi.nlm.nih.gov/pubmed/28049023 https://www.ncbi.nlm.nih.gov/pubmed/17684524 https://www.ncbi.nlm.nih.gov/pubmed/17684524 http://www.sciencedirect.com/science/article/pii/S1043661805001404 http://www.sciencedirect.com/science/article/pii/S1043661805... https://diabetesjournals.org/care/article/doi/10.2337/dc23-0206/153434/Artificial-Sweeteners-and-Risk-of-Type-2-Diabetes https://diabetesjournals.org/care/article/doi/10.2337/dc23-0... https://www.ncbi.nlm.nih.gov/pubmed/27997218 https://www.ncbi.nlm.nih.gov/pubmed/27997218 http://www.massgeneral.org/News/pressrelease.aspx?id=2016 http://www.massgeneral.org/News/pressrelease.aspx?id=2016 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772345/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772345/
- BurningFrog 3y ago
  > * reduced metabolism (leading to more weight gain than a subjectively equivalent amount of sugar),* Doesn't that mean aspartame somehow contains more energy than sugar? I mean, assuming the increased weight is fat, that is stored extra energy.
  - mpol 3y ago
    The idea works longterm. You take aspartame, which has a sweet taste but no energy. Your body starts all kinds of digestive functions and gets confused. After a lot of aspartame it doesn't know how to respond to sweet food anymore.
  - oaktrout 3y ago
    There is some evidence that artificial sweeteners increase insulin resistance: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014832/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014832/ I have also heard that because artificial sweeteners increase insulin levels without increasing blood glucose to the same extent that sugars would, this leads to a blood sugar drop which induces increased eating.
- Lord-Jobo 3y ago
  Decades of research have found rare, but still very mildly negative health results from aspartame, and an overwhelming flood of direct evidence for strong negative health effects from sugar. Back up what you are saying with some studies. Because what you are claiming is going against a LOT of modern medical knowledge.
  - willmadden 3y ago
    Are you kidding? Aspartame is horrible for you. Dozens of studies link it to cancer, cardiovascular disease, Alzheimer’s, seizures, stroke and dementia, as well as negative effects such as intestinal dysbiosis, mood disorders, headaches and migraines. It's also linked to weight gain and obesity.
- deleted 3y ago
  [deleted]
bborud 3y ago
Regardless of whether aspartame is better or worse than sugars (I neither know nor care) that sounds awful. I find the taste of aspartame revolting.

>and another which results in reduced glucose and fructose content in the potato, That's pretty amazing. Imagine if we can change apples to produce Aspartame instead of sugars!

iwontberude 3y ago

I don’t see how a plant is supposed to metabolize the aspartame for energy?

maxerickson 3y ago
It would only be a successful reproductive strategy if some external actor decided to propagate the plants that were putting something not useful to the seeds into the fruit.

hedora 3y ago

Unless you are diabetic, aspartame is much worse for you than sugar. It causes metabolic issues, such as reduced metabolism (leading to more weight gain than a subjectively equivalent amount of sugar), migraines in some people, interacts with drugs, is bad for your digestive tract, and probably has other side effects. Even if you are diabetic, you can already eat apples. They have a low glycemic index.

liamwire 3y ago
Extraordinary claims require extraordinary evidence. Can you back any of this up, or provide a reason I should believe what you’re saying? Because it directly contradicts decades of research on what is perhaps the most scrutinised and studied dietary supplement in the world. Aspartame is safe, and very well tolerated. You’re spreading misinformation.
- willmadden 3y ago
  You are the one spreading misinformation. Aspartame is horrible for you. Here, have a read. I have more if you would like them. https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1003950 https://journals.plos.org/plosmedicine/article?id=10.1371/jo... https://www.sciencedaily.com/releases/2022/03/220324143800.htm https://www.sciencedaily.com/releases/2022/03/220324143800.h... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1392232/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1392232/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1964906/pdf/ehp0115-001293.pdf http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1964906/pdf/ehp0... http://www.mpwhi.com/soffritti_2010_20896_fta.pdf http://www.mpwhi.com/soffritti_2010_20896_fta.pdf https://ehjournal.biomedcentral.com/articles/10.1186/s12940-021-00725-y https://ehjournal.biomedcentral.com/articles/10.1186/s12940-... https://annalsofglobalhealth.org/articles/10.5334/aogh.4163 https://annalsofglobalhealth.org/articles/10.5334/aogh.4163 http://ajcn.nutrition.org/content/96/6/1419.long http://ajcn.nutrition.org/content/96/6/1419.long https://www.ncbi.nlm.nih.gov/pubmed/24436139 https://www.ncbi.nlm.nih.gov/pubmed/24436139 https://www.pnas.org/doi/10.1073/pnas.2213120119 https://www.pnas.org/doi/10.1073/pnas.2213120119 https://news.fsu.edu/news/university-news/2022/12/08/fsu-research-links-common-sweetener-with-anxiety/ https://news.fsu.edu/news/university-news/2022/12/08/fsu-res... https://www.nature.com/articles/s41598-023-41213-2 https://www.nature.com/articles/s41598-023-41213-2 https://www.ncbi.nlm.nih.gov/pubmed/8939194 https://www.ncbi.nlm.nih.gov/pubmed/8939194 https://www.youtube.com/watch?v=yCoBuTr0Or0 https://www.youtube.com/watch?v=yCoBuTr0Or0 http://www.cmaj.ca/content/189/28/E929 http://www.cmaj.ca/content/189/28/E929 https://www.statnews.com/2017/07/17/artificial-sweeteners-weight-loss/ https://www.statnews.com/2017/07/17/artificial-sweeteners-we... https://blogs.wsj.com/experts/2017/09/14/why-one-cardiologist-has-drunk-his-last-diet-soda/ https://blogs.wsj.com/experts/2017/09/14/why-one-cardiologis... https://www.philly.com/philly/health/this-cardiologist-wants-his-family-to-cut-back-on-diet-soda-should-yours-too-20170912.html https://www.philly.com/philly/health/this-cardiologist-wants... https://www.ncbi.nlm.nih.gov/pubmed/27129676 https://www.ncbi.nlm.nih.gov/pubmed/27129676 http://stroke.ahajournals.org/content/early/2017/04/20/STROKEAHA.116.016027 http://stroke.ahajournals.org/content/early/2017/04/20/STROK... https://www.bumc.bu.edu/busm/2017/04/20/daily-consumption-of-sodas-fruit-juices-and-artificially-sweetened-sodas-affect-brain/ https://www.bumc.bu.edu/busm/2017/04/20/daily-consumption-of... https://www.washingtonpost.com/news/morning-mix/wp/2017/04/21/study-links-diet-soda-to-higher-risk-of-stroke-dementia/?utm_term=.2bfedb009058 https://www.washingtonpost.com/news/morning-mix/wp/2017/04/2... https://www.ncbi.nlm.nih.gov/pubmed/24787915 https://www.ncbi.nlm.nih.gov/pubmed/24787915 https://www.ncbi.nlm.nih.gov/pubmed/24787917 https://www.ncbi.nlm.nih.gov/pubmed/24787917 https://www.ncbi.nlm.nih.gov/pubmed/1579221 https://www.ncbi.nlm.nih.gov/pubmed/1579221 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474447/pdf/envhper00434-0053.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474447/pdf/env... https://www.ncbi.nlm.nih.gov/pubmed/28198207 https://www.ncbi.nlm.nih.gov/pubmed/28198207 https://www.ncbi.nlm.nih.gov/pubmed/28049023 https://www.ncbi.nlm.nih.gov/pubmed/28049023 https://www.ncbi.nlm.nih.gov/pubmed/17684524 https://www.ncbi.nlm.nih.gov/pubmed/17684524 http://www.sciencedirect.com/science/article/pii/S1043661805001404 http://www.sciencedirect.com/science/article/pii/S1043661805... https://diabetesjournals.org/care/article/doi/10.2337/dc23-0206/153434/Artificial-Sweeteners-and-Risk-of-Type-2-Diabetes https://diabetesjournals.org/care/article/doi/10.2337/dc23-0... https://www.ncbi.nlm.nih.gov/pubmed/27997218 https://www.ncbi.nlm.nih.gov/pubmed/27997218 http://www.massgeneral.org/News/pressrelease.aspx?id=2016 http://www.massgeneral.org/News/pressrelease.aspx?id=2016 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772345/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772345/
BurningFrog 3y ago
> * reduced metabolism (leading to more weight gain than a subjectively equivalent amount of sugar),* Doesn't that mean aspartame somehow contains more energy than sugar? I mean, assuming the increased weight is fat, that is stored extra energy.
- mpol 3y ago
  The idea works longterm. You take aspartame, which has a sweet taste but no energy. Your body starts all kinds of digestive functions and gets confused. After a lot of aspartame it doesn't know how to respond to sweet food anymore.
- oaktrout 3y ago
  There is some evidence that artificial sweeteners increase insulin resistance: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014832/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014832/ I have also heard that because artificial sweeteners increase insulin levels without increasing blood glucose to the same extent that sugars would, this leads to a blood sugar drop which induces increased eating.
Lord-Jobo 3y ago
Decades of research have found rare, but still very mildly negative health results from aspartame, and an overwhelming flood of direct evidence for strong negative health effects from sugar. Back up what you are saying with some studies. Because what you are claiming is going against a LOT of modern medical knowledge.
- willmadden 3y ago
  Are you kidding? Aspartame is horrible for you. Dozens of studies link it to cancer, cardiovascular disease, Alzheimer’s, seizures, stroke and dementia, as well as negative effects such as intestinal dysbiosis, mood disorders, headaches and migraines. It's also linked to weight gain and obesity.
deleted 3y ago
[deleted]

bborud 3y ago

Regardless of whether aspartame is better or worse than sugars (I neither know nor care) that sounds awful. I find the taste of aspartame revolting.