5 ms·
The Domestication of SARS-CoV-2 into a Seasonal Infection by Viral Variants
- dmix 3y agoIs the full study accessible here?
- coldcode 3y agoThere is no article yet, it hasn't been posted.
- idiotsecant 3y agoCOVID sure was fun, See you guys at the next one!
- MichaelRo 3y agoProbably won't take long until then. These pandemics are so common that 4 million deaths barely registered on the radar and were forgotten by history: https://en.wikipedia.org/wiki/1957%E2%80%931958_influenza_pandemic https://en.wikipedia.org/wiki/1957%E2%80%931958_influenza_pa... https://insights.som.yale.edu/insights/the-history-of-the-forgotten-pandemic https://insights.som.yale.edu/insights/the-history-of-the-fo...
- chx 3y agoPeople don't like to hear that COVID is airborne, that COVID is not over, and that COVID is NOT a respiratory illness but a vascular illness that causes multisystem organ damage, but this is true, and our governments don't fucking care who dies or becomes permanently disabled as long as people keep contributing to capitalism. So MOST GOVERNMENTS ARE NOW SOURCES OF COVID MISINFORMATION.
- kelipso 3y agoPeople want to live. And they don't want to do the Covid years again. Capitalism is not relevant here.
- swed420 3y agoExactly, but you sure wouldn't know it in most areas these days. Only in niche corners like r/ZeroCovidCommunity can you find actually useful information about this ongoing public health disaster. The only sure protection available is wearing a properly fitted N95 respirator in public spaces. Unfortunately this is a tall ask for most people.
- chx 3y ago> The only sure protection available is wearing a properly fitted N95 respirator in public spaces. I ... am not 100% about that and can't afford mistakes so I wear a PAPR with a HEPA filter in public spaces and hate the world for forcing me to do so. (It's a Cleanspace Halo.)
- swed420 3y agoStudies confirm that N95s effectively protect the individual from SARS-CoV-2 transmission (contrary to all of the misinformation saying otherwise). If you can afford something fancier, great. My above comment was to differentiate N95s from surgical/cloth masks as well as vaccines, because these latter methods are not enough to stop transmission, and repeated infections increase the risk of Long COVID / PASC complications.
- the_third_wave 3y agoStudies confirm whatever standpoint you want, other studies disprove the same standpoint [1] for those who want to wave the "studies confirm" stick. [1] https://www.thebottomline.org.uk/summaries/danmask-19/ https://www.thebottomline.org.uk/summaries/danmask-19/
- swed420 3y agoA good starting point is using current data. Your study is from 2020 and is an apples-oranges comparison to my original point. By now the research (as interpreted by experts, not internet randos) have coelesced around the fact that a properly fitted N95 provides the wearer adequate protection against SARS-CoV-2 transmission. There has been a push to drive false information around this basic topic as one of the many tactics to force the "back to normal" behavior that capital demands. Mass media trying to suggest lesser masks (and/or vaccines) are sufficient, resulting in false "all masks don't work" conclusions, etc.
- zaebal 3y agoThe whole multisystem-organ-damaged world is conspiring against you.
- russfink 3y agoWhat does it mean, “more infectious and less virulent?” Does that mean less dangerous if you catch it?
- goalieca 3y ago> We observed a decrease in COVID-19 disease severity surrogates after the arrival of the Delta variant, coinciding with significantly smaller plaque sizes. The sentence before leads to the claim. Surrogate is the key word here since it’s really hard to directly quantify.
- zethus 3y agoMore infectious: easier to spread & catch Less virulent: less harmful when caught
- samus 3y agoYes, although it's still by definition not a good idea to catch a disease. If it hits you too hard, you stay home, get quarantined, or put into a hospital. But it has to cause at least some reaction in the host, else there wouldn't be any coughing and sneezing to begin with.
- largbae 3y agoHSV-1 (cold sores) might be the ultimate example of success, it manages to spread essentially invisibly.
- deleted 3y ago[deleted]
- wolfram74 3y agoOn average, yes. This is also the tendency for most diseases, too evolve into a form less destructive to their habitat so it's easier for them to get to new places to infect. Given that this is biology I will note there are surely counter examples and variations on how fast this trend takes place.
- ramesh31 3y agoI came to that realization this fall, as everyone started getting sick again. I played mine off as just a cold as well, but we all know it was COVID. It was always inevitable that this would become endemic. It just sucks being the generation that had to build the immunity.
- ch4s3 3y ago> but we all know it was COVID Did you test? I had a bad cold several weeks back and after 3 tests it's clear that it wasn't COVID.
- ramesh31 3y ago>Did you test? I had a bad cold several weeks back and after 3 tests it's clear that it wasn't COVID. I did not, but multiple family members did. Not much point anymore unless you're high risk. We've all got it, and no one's going back to wearing masks again.
- ch4s3 3y agoI hear you, but it's maybe worth knowing if you end up with any post viral stuff even if that's kind of rare.
- zoklet-enjoyer 3y agoFunny you say this, because where I work, we wear masks if we've had contact with someone with COVID and after coming back to work after being gone with COVID. Unless you're talking about masking all day everyday.
- j-wags 3y agoYeah, wife and I just had covid and we broke out the masks for a few days. We'll probably do the same if we get the flu. I figure we've got 20 neighbors on our floor and maybe 10 are likely to get flu/covid in the next 12 months, so I'd be directly responsible if I got the 11th one sick in the elevator. That said, it wasn't that inconvenient since we're wfh, so I can see why people do different math.
- ginko 3y agoI wonder if such a virus domestication could be somehow done in-vitro. Probably would only make sense at the very beginning of a (new) pandemic.
- dheera 3y agoEven if it were possible, it wouldn't control the ones circulating in the wild.
- ginko 3y agoThe idea would be that the "domesticated" variant is more infectious so it would outcompete the wild ones.
- ramesh31 3y ago>The idea would be that the "domesticated" variant is more infectious so it would outcompete the wild ones. This is precisely what the gain-of-function research that was happening in Wuhan tried to do. Whether that was a good idea or not is now questionable.
- 9question1 3y agoActually, gain of function research that's been criticized has been criticized mainly for increasing virulence. The post you're responding to here is asking about in vitro research to decrease virulence.
- 9question1 3y ago```if ... virus domestication could be somehow done in-vitro``` This is basically the definition of a vaccine, except that the vaccine has 0 infectiousness and near 0 virulence, rather than high infectiousness and near 0 virulence
- peteradio 3y ago> and near 0 virulence Covid vaccine does not have near 0 side-effects.
- Zealotux 3y agoI wonder what the implications are for COVID in the long term. After catching it the first time, I lost all smell and taste for two months, and I can say my taste has been altered probably forever because of it. Does this mean I could catch it again and get anosmia regularly? What about long COVID?
- deleted 3y ago[deleted]
- southernplaces7 3y agoJust a personal anecdote: I got covid a total of four times (tested for and verified insofar as such tests are reliable) Two of these were post-vaccination with Pfizer. Each time was lighter than the previous occasion. The first time felt like a nasty but short case of the flu, the second one like a moderate cold with very low fever, and the latter two times like minor head colds basically with no fever at all. In my case I only lost my sense of smell and taste the first time, but only for a few days, similar to how the flu can sometimes do as well. Never got so-called long-COVID, which seems to be rather ambiguous as a clinical condition (not arguing it doesn't exist, but there's lots left to investigate and much self-reported diagnosis that I frankly don't trust around many reports of it) Some people get it differently from others and even now it can hit certain individuals ferociously, but it always was absurd to think that this virus would simply go away, as some people argued. That it should evolve into a milder variant like many other seasonal cold-like viruses made sense given the vast number of people it infected, allowing it to keep evolving dynamically. Some widespread viruses don't do this quite so much of course. Smallpox being an infamous example that never stopped being extremely deadly until it was eradicated, but that doesn't mean it can't reliably happen to other types of viral infections in certain biological categories.