More of a broader/long term question, would it be possible to design/use a smaller motherboard? I recognise this is a bit of an unusual question, but the advant

More of a broader/long term question, would it be possible to design/use a smaller motherboard? I recognise this is a bit of an unusual question, but the advantage of a small motherboard is being able to use it in all kinds of tablet/cyberdeck-esqe enclosures. Aaeon offers a 3.5” SBC with nearly every new generation of Intel processors, and while they’re commercial/industrial oriented (and therefore expensive), it shouldn’t be too hard for something like a common 4”*4” NUC form factor. A smaller board can fit a large laptop (and give more space for other components too).