4 ms·

Based on https://slatestarcodex.com/2018/07/10/melatonin-much-more-than-you-wanted-to-know/ https://slatestarcodex.com/2018/07/10/melatonin-much-more-th..., as

by strken 3y ago

Based on https://slatestarcodex.com/2018/07/10/melatonin-much-more-than-you-wanted-to-know/ https://slatestarcodex.com/2018/07/10/melatonin-much-more-th..., as well as every chart of melatonin I can find, it doesn't seem to peak during the day. It seems to rise before bedtime and peak in the early hours of sleep. According to the blog post, the treatment for some sleep disorders is to take a dose of melatonin during the day, which moves your natural melatonin production earlier for unclear reasons. Maybe there's confusion between when you take the melatonin and when melatonin is naturally highest?

naruhodo 3y ago
Yeah, it was my understanding that melatonin is secreted under low-light conditions according to one's circadian rhythm. > A substantial number of studies have shown that, within this rhythmic profile, the onset of melatonin secretion under dim light conditions (the dim light melatonin onset or DLMO) is the single most accurate marker for assessing the circadian pacemaker. Additionally, melatonin onset has been used clinically to evaluate problems related to the onset or offset of sleep. DLMO is useful for determining whether an individual is entrained (synchronized) to a 24-h light/dark (LD) cycle or is in a free-running state. DLMO is also useful for assessing phase delays or advances of rhythms in entrained individuals. Additionally, it has become an important tool for psychiatric diagnosis, its use being recommended for phase typing in patients suffering from sleep and mood disorders. More recently, DLMO has also been used to assess the chronobiological features of seasonal affective disorder (SAD). DLMO marker is also useful for identifying optimal application times for therapies such as bright light or exogenous melatonin treatment. [1] [1] https://pubmed.ncbi.nlm.nih.gov/16884842/ https://pubmed.ncbi.nlm.nih.gov/16884842/

by strken 3y ago

naruhodo 3y ago

Yeah, it was my understanding that melatonin is secreted under low-light conditions according to one's circadian rhythm. > A substantial number of studies have shown that, within this rhythmic profile, the onset of melatonin secretion under dim light conditions (the dim light melatonin onset or DLMO) is the single most accurate marker for assessing the circadian pacemaker. Additionally, melatonin onset has been used clinically to evaluate problems related to the onset or offset of sleep. DLMO is useful for determining whether an individual is entrained (synchronized) to a 24-h light/dark (LD) cycle or is in a free-running state. DLMO is also useful for assessing phase delays or advances of rhythms in entrained individuals. Additionally, it has become an important tool for psychiatric diagnosis, its use being recommended for phase typing in patients suffering from sleep and mood disorders. More recently, DLMO has also been used to assess the chronobiological features of seasonal affective disorder (SAD). DLMO marker is also useful for identifying optimal application times for therapies such as bright light or exogenous melatonin treatment. [1] [1] https://pubmed.ncbi.nlm.nih.gov/16884842/ https://pubmed.ncbi.nlm.nih.gov/16884842/