4 ms·

> The winners will have to prove by 2030 that their intervention can turn back the clock in older adults by at least a decade in three key areas: cognition, imm

> The winners will have to prove by 2030 that their intervention can turn back the clock in older adults by at least a decade in three key areas: cognition, immunity, and muscle function. Can't you already get that just by exercising?

Gualdrapo 3y ago
People rather like miracles and low effort results.
- toomuchtodo 3y ago
  And we will pay incredible amounts for them. The Danish central bank is holding interest rates below that of the ECB due to how successful Ozempic and Wegovy are [1] [2]. It's expected to be a $100B market by 2035 (assuming "one and done" gene therpay doesn't fast takeoff [3]). [1] https://www.cnn.com/2023/08/21/business/ozempic-wegovy-demand-denmark-economy/index.html https://www.cnn.com/2023/08/21/business/ozempic-wegovy-deman... [2] https://fortune.com/2023/09/22/obesity-drug-market-ozempic-wegovy-2035/ https://fortune.com/2023/09/22/obesity-drug-market-ozempic-w... [3] https://news.ycombinator.com/item?id=38495653 https://news.ycombinator.com/item?id=38495653 (if I can get the benefits of exercise without exercising, "shut up and take my money"; success is about outcomes, not effort)
  - RandomLensman 3y ago
    Just in case: The Danish Central Bank is reacting to the economic success of the drug maker which impacts the currency flows and thereby the currency peg they are managing. (Not some health benefits thing by the central bank).
    - deleted 3y ago
      [deleted]
    - mensetmanusman 3y ago
      America exporting the disorder of the US healthcare system and crashing currencies as we help companies become larger than their nation state GDPs. Kind of funny actually.
      - RandomLensman 3y ago
        No currency crashing with DKK.
- BurningFrog 3y ago
  Of course we do. Nothing wrong with that!
- kiba 3y ago
  That would be like investing into a single stock, and hoping that your investment pans out. You diversify your investments to reduce the risk of catastrophic loss. I would like to encourage maximum effort into maintaining my health while waiting for interventions to develop. This is all on top of competing priorities such as projects I am working on.
dghughes 3y ago
No I'd say by being active you are being the best you can be and also maintaining as best you can your body but it will still degrade. If you're out of shape so you decide to be more active, eat well, you fell better. You will gain muscle lose excess fat eventually you arrive at a level of health that is normal. You will be as healthy as we all should be. This is something I think many people miss about being active. When I was in my 20s and 30s the gym was a social thing, to see and be seen. Plus being 20s you can build muscle, get fit, do anything and recover in a day. In my 40s I felt I was ahead of most people in overall health no gut no out of breath from menial tasks. By health I don't mean the "swol bros" or the gaunt 1% fat people. But in my late 30s early 40s my routine suffered and then stopped going due to a new job with odd hours. Although I did feel I had momentum of all those years but it faded quickly. It was the consistency of going more than anything that I think was a benefit to my health. I wasn't a power lifter, a marathon runner, a body builder, one of those squash players I was just going to maintain my overall health. Really it's a bit like countries with socialized medical care. You go often and catch problems early so you are better overall not near death's door when you finally go to a doctor. Same for a dentist you go frequently to catch problems since you can't regrow teeth it's too late then. Old age without being active in the previous decades is like that it's too late.
BurningFrog 3y ago
Not if you already are exercising.
qgin 3y ago
You can make your health in older age worse by not exercising. But no amount of exercising can fight aging.
jamesTee49 3y ago
Need creatine monohydrate maybe around 5-12g daily depending on age. I have seen MANY 60+ that look like late 30s simply keeping a daily creatine supplement religiously. Weight lifting prefer especially having bones being stressed compare to cardios.

Gualdrapo 3y ago

People rather like miracles and low effort results.

toomuchtodo 3y ago
And we will pay incredible amounts for them. The Danish central bank is holding interest rates below that of the ECB due to how successful Ozempic and Wegovy are [1] [2]. It's expected to be a $100B market by 2035 (assuming "one and done" gene therpay doesn't fast takeoff [3]). [1] https://www.cnn.com/2023/08/21/business/ozempic-wegovy-demand-denmark-economy/index.html https://www.cnn.com/2023/08/21/business/ozempic-wegovy-deman... [2] https://fortune.com/2023/09/22/obesity-drug-market-ozempic-wegovy-2035/ https://fortune.com/2023/09/22/obesity-drug-market-ozempic-w... [3] https://news.ycombinator.com/item?id=38495653 https://news.ycombinator.com/item?id=38495653 (if I can get the benefits of exercise without exercising, "shut up and take my money"; success is about outcomes, not effort)
- RandomLensman 3y ago
  Just in case: The Danish Central Bank is reacting to the economic success of the drug maker which impacts the currency flows and thereby the currency peg they are managing. (Not some health benefits thing by the central bank).
  - deleted 3y ago
    [deleted]
  - mensetmanusman 3y ago
    America exporting the disorder of the US healthcare system and crashing currencies as we help companies become larger than their nation state GDPs. Kind of funny actually.
    - RandomLensman 3y ago
      No currency crashing with DKK.
BurningFrog 3y ago
Of course we do. Nothing wrong with that!
kiba 3y ago
That would be like investing into a single stock, and hoping that your investment pans out. You diversify your investments to reduce the risk of catastrophic loss. I would like to encourage maximum effort into maintaining my health while waiting for interventions to develop. This is all on top of competing priorities such as projects I am working on.

dghughes 3y ago

No I'd say by being active you are being the best you can be and also maintaining as best you can your body but it will still degrade. If you're out of shape so you decide to be more active, eat well, you fell better. You will gain muscle lose excess fat eventually you arrive at a level of health that is normal. You will be as healthy as we all should be. This is something I think many people miss about being active. When I was in my 20s and 30s the gym was a social thing, to see and be seen. Plus being 20s you can build muscle, get fit, do anything and recover in a day. In my 40s I felt I was ahead of most people in overall health no gut no out of breath from menial tasks. By health I don't mean the "swol bros" or the gaunt 1% fat people. But in my late 30s early 40s my routine suffered and then stopped going due to a new job with odd hours. Although I did feel I had momentum of all those years but it faded quickly. It was the consistency of going more than anything that I think was a benefit to my health. I wasn't a power lifter, a marathon runner, a body builder, one of those squash players I was just going to maintain my overall health. Really it's a bit like countries with socialized medical care. You go often and catch problems early so you are better overall not near death's door when you finally go to a doctor. Same for a dentist you go frequently to catch problems since you can't regrow teeth it's too late then. Old age without being active in the previous decades is like that it's too late.

BurningFrog 3y ago

Not if you already are exercising.

qgin 3y ago

You can make your health in older age worse by not exercising. But no amount of exercising can fight aging.

jamesTee49 3y ago

Need creatine monohydrate maybe around 5-12g daily depending on age. I have seen MANY 60+ that look like late 30s simply keeping a daily creatine supplement religiously. Weight lifting prefer especially having bones being stressed compare to cardios.