3 ms·

I first heard of “the weight loss shot” from a morbidly obese waste management company owner friend of mine. He has steadily lost weight and kept it off with wh

I first heard of “the weight loss shot” from a morbidly obese waste management company owner friend of mine. He has steadily lost weight and kept it off with what is basically a chemically induced fast. So it clearly works. Anything that measurably reverses the insane growth rate of obesity is very welcome. If all it takes is a weekly shot to reliably improve individual decision making with consumption then that would legitimately be revolutionary. No free lunch still applies though, I’ll be interested to see what the long term externalities are.

SOLAR_FIELDS 3y ago
It reminds me of accutane in a lot of ways. Some drugs are actually miraculous in how they solve problems, but can have some pretty nasty side effects. I wonder if Ozempic will end up like accutane as the final line of treatment when all other routes have been exhausted, or if the formulation will be refined to the point the side effects become minimal. One interesting difference between Ozempic and accutane is that the accutane treatment is pretty much permanent after a dosage round but it seems like this Ozempic needs to be continuously taken to see effects. Which is great news for pharm companies
- rblatz 3y ago
  Side effects are generally mild on ozempic like acid reflux and can be controlled easily with a PPI like pantoprazole. Accutane was absolute hell.
toomuchtodo 3y ago
This is just a first step towards GLP-1 gene therapy. It works in mice and pig models so far. Piece by piece, we spellcheck the genome. Human trials are targeted for next year. https://www.fiercebiotech.com/research/fractyls-gene-therapy-obesity-outdoes-semaglutide-weight-loss-mice https://www.fiercebiotech.com/research/fractyls-gene-therapy... https://www.fractyl.com/fractyl-health-demonstrated-significant-improvement-in-weight-loss-in-head-to-head-preclinical-obesity-studies-of-its-rejuva-glp-1-based-pancreatic-gene-therapy-candidate-glp-1-pgtx-compared-to-chr/ https://www.fractyl.com/fractyl-health-demonstrated-signific... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812410/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812410/

SOLAR_FIELDS 3y ago

It reminds me of accutane in a lot of ways. Some drugs are actually miraculous in how they solve problems, but can have some pretty nasty side effects. I wonder if Ozempic will end up like accutane as the final line of treatment when all other routes have been exhausted, or if the formulation will be refined to the point the side effects become minimal. One interesting difference between Ozempic and accutane is that the accutane treatment is pretty much permanent after a dosage round but it seems like this Ozempic needs to be continuously taken to see effects. Which is great news for pharm companies

rblatz 3y ago
Side effects are generally mild on ozempic like acid reflux and can be controlled easily with a PPI like pantoprazole. Accutane was absolute hell.

toomuchtodo 3y ago

This is just a first step towards GLP-1 gene therapy. It works in mice and pig models so far. Piece by piece, we spellcheck the genome. Human trials are targeted for next year. https://www.fiercebiotech.com/research/fractyls-gene-therapy-obesity-outdoes-semaglutide-weight-loss-mice https://www.fiercebiotech.com/research/fractyls-gene-therapy... https://www.fractyl.com/fractyl-health-demonstrated-significant-improvement-in-weight-loss-in-head-to-head-preclinical-obesity-studies-of-its-rejuva-glp-1-based-pancreatic-gene-therapy-candidate-glp-1-pgtx-compared-to-chr/ https://www.fractyl.com/fractyl-health-demonstrated-signific... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812410/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812410/