Fun fact: the way they were able to get those nice images of the collagen in the tendons was by utilizing an optical imaging method called Second Harmonic Gener

Fun fact: the way they were able to get those nice images of the collagen in the tendons was by utilizing an optical imaging method called Second Harmonic Generation. Collagen intrinsically produces a very strong SHG signal without the need to attach any labels to the collagen. SHG is also a 3D imaging method that can be used to image deep inside live tissues (instead of having to fix, section and label the tissue like most histology methods) and thus they were able to monitor the tendon repair over time in a living system.