3 ms·
Funny that the first several dozen comments I read don’t comment at all on the OP. Dog stories are irresistible ;-) Let me do that in case anyone cares about t
by robwwilliams 3y ago
Funny that the first several dozen comments I read don’t comment at all on the OP. Dog stories are irresistible ;-)
Let me do that in case anyone cares about the science.
The treatment is a proprietary drug to inhibit IGF1 signaling. If applied early in life (puppy stage) this would reduce growth rates and result in smaller adult body size. Lots of data on life and health extension via trimming back insulin-IGF signaling. But to the best of my knowledge, this should not be particularly effective later in life.
Later in life (1 year old pet mouse, 5 year old dog, 60 year old human) you would want to treat with intermittent rapamycin or other mTOR-C1 complex inhibitors.
This works very well in male and female mice and is now being tested by Matt Kaeberlein and many colleagues in dogs and humans.
There is a vibrant community of biohackers—-mostly rididulously healthy and relative rich and well informed humans older than 40, who are testing rapamycin at a mean dose of about 5 mg once per week. No marked negatives except what you would expect—somewhat less vigorous immune responses. You don’t want to take rapamycin if you are a 60-year-old kindergarten teacher!
See Matt’s site: https://mkaeberlein.com/off-label-rapamycin/ https://mkaeberlein.com/off-label-rapamycin/
- kilroy123 3y agoDo you recommend any other biohacker blogs or people to follow? I know YouTube shut down several biohacker channels.
- philg_jr 3y agoPeter Attia, but he is focused on things that are well studied and concentrates on the low hanging fruit, eg. mental health, diet, and exercise.
- theatraine 3y agoJosh Mitteldorf's blog is good for life extension updates: https://joshmitteldorf.scienceblog.com/ https://joshmitteldorf.scienceblog.com/
- klipt 3y ago> The treatment is a proprietary drug to inhibit IGF1 signaling. If applied early in life (puppy stage) this would reduce growth rates and result in smaller adult body size. So make large dogs live longer by turning them into smaller dogs, essentially? It's funny that we humans seem to be sexually selecting ourselves to be taller and taller even though that seems to also cause shorter lifespans.
- nextos 3y agoWhat I would like to know is how big the effect size is. NYT published a detailed article and it looks much more cautious than other news outlets: https://www.nytimes.com/2023/11/28/science/longevity-drugs-dogs.html https://www.nytimes.com/2023/11/28/science/longevity-drugs-d... According to Celine, they will be eventually "claiming at least one year of healthy life span extension", so it looks like the effect will be moderate. Still interesting. Dairy raises IGF-1 levels. This is why I think that getting too hooked on dairy products beyond age 50 is not a good idea.
- throwaway290 3y agoIs that the same for lactose-free dairy?
- nextos 3y agoI think so, as cheese that is in practice lactose free due to long fermentation does raise IGF too.
- hoseja 3y agoAll diary or just american antibiotic and growth hormone-filled diary?
- wolverine876 3y agoIs there any published research of controlled trials? > mostly rididulously healthy and relative rich and well informed humans older than 40 That reads like promotion. Also, how is wealth implicated here?
- Snoddas 3y agoprobably because biohacking has a reputation for being rather expensive A nbc news clip: https://www.youtube.com/watch?v=Wc5CRvzzywU https://www.youtube.com/watch?v=Wc5CRvzzywU