Had to deal with a few nightmare scenarios for a client with runaway costs due to high read/writes on a piece of software they were using that used SQLite on EF

Had to deal with a few nightmare scenarios for a client with runaway costs due to high read/writes on a piece of software they were using that used SQLite on EFS + ECS as the infrastructure layer. Short answer you can do it, but it will get expensive if you do any significant amount of writes. I do wish AWS would release a SQLite compatible database though. Maybe this week during Reinvent.