I'm not saying everything is known. The question is, are there any questions we can ask that have a potential answer that will not be answered by a material, me

I'm not saying everything is known. The question is, are there any questions we can ask that have a potential answer that will not be answered by a material, mechanical description. Because we already know what that entails. Can you conceive of an explanation of the fine structure constant or any other question in physics, or any other domain of science that doesn't have a material mechanical basis as the answer? If not, then all the answers are variations on each other. To be fair, in some sense that project has already broken down. We have 'fields' in empty space, 'virtual' particles, correlation over distances where causation is not possible, and other things that, basically, are inconceivable.