A development version of pipx supports a feature that address this pain point. See pull request #916 [1] In your script example.py, you would specify your depe

A development version of pipx supports a feature that address this pain point. See pull request #916 [1] In your script example.py, you would specify your dependencies in a special comment like this: # Requirements: # requests import requests ... Then you could run the script like this: pipx run file:example.py This would install the dependencies in a temporary virtual environment, and run the script in that virtual environment. [1] https://github.com/pypa/pipx/pull/916 https://github.com/pypa/pipx/pull/916