Are you talking about using it AIO? It seems preferable to me in general to have VMs live on external storage like a NAS. Proxmox, KVM, Xen and I assume everyth

Are you talking about using it AIO? It seems preferable to me in general to have VMs live on external storage like a NAS. Proxmox, KVM, Xen and I assume everything else all support using iSCSI at least. Then your storage layer can focus on that and handle all the backing up, data integrity etc itself. I guess that does raise cost for the same performance vs a single box so it'll depend on budget/needs, but it's getting pretty affordable with a bit of shopping to do some serious storage devices these days.