Agree, most work seems to treat the brain as the sole locus of neurological activity when the brain is one piece of a system. To give a parallel, your high blo

Agree, most work seems to treat the brain as the sole locus of neurological activity when the brain is one piece of a system. To give a parallel, your high blood pressure may not be due to your heart, as it may be responding to a system of factors. Vasodilation and vasoconstriction of blood vessels have a direct impact. Your kidney health, an organ outside of your circulatory system can trigger high blood pressure. O2 and CO2 levels in the blood can trigger a response. Looking at the brain in a vacuum will only get us so far.