3 ms·
So this is really cool. I've been super interested in this one gene mutation called LRRK2 which has a really bizarre link to details in contentious debates over
by kromem 3y ago
So this is really cool. I've been super interested in this one gene mutation called LRRK2 which has a really bizarre link to details in contentious debates over history (too long to include in this comment).
The gene mutation is connected to both Crohn's disease and Parkinson's.
So after seeing this article about how glial issues are connected to Crohn's, my immediate thought was - well, what about Parkinson's?
And indeed, it looks like the LRRK2 mutation contributes to Parkinson's by screwing up the glial cells:
Is Glial Dysfunction the Key Pathogenesis of LRRK2-Linked Parkinson’s Disease? (2023): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856048/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856048/
(I can't wait for LLMs to advance enough that parallel discoveries in subdomains are teased out as further cross discipline research candidates.)
- apienx 3y agohttps://www.nature.com/articles/s41467-023-36497-x https://www.nature.com/articles/s41467-023-36497-x
- zacmps 3y agoLLMs also have huge potential for helping us understand genetics, see Facebook's ESM for example.
- kromem 3y agoOne of the cool discoveries in Anthropic's approach to introspection by functional grouping of neural network nodes was that there was a series of nodes dedicated to firing when it was looking at a DNA sequence.