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Other than the general shortcomings of a rat study, does this result run counter to your understanding of the effects of stress on genetic expression in the bra
by svnt 3y ago
Other than the general shortcomings of a rat study, does this result run counter to your understanding of the effects of stress on genetic expression in the brain?
My understanding is that early childhood stress in humans has also been fairly reliably linked to things such as “psychopathic” behaviors. e.g. [0]
[0] https://www.academia.edu/download/89809148/2128.pdf https://www.academia.edu/download/89809148/2128.pdf
- robwwilliams 3y agoMost neuroscientists would expect TBI to be linked to regional micoglial activation. And perhaps activated GFAP-positive astrocytes. Psychosocial stress will have different effects mediated in part by the hypothalamus-pituitary-adrenal system. There may be some postmortem RNAseq studies of humans, even small pediatric cohort, but I did not find them in PubMed. I did find this treatment approach for TBI (yes, in mice) https://pubmed.ncbi.nlm.nih.gov/33540074/ https://pubmed.ncbi.nlm.nih.gov/33540074/
- svnt 3y agoIsn’t it more that it is just extremely difficult if not impossible to do the necessary longitudinal study in humans? You’d need verified quantified early trauma, lack of possible TBI, and early death, and RNAseq processing postmortem which is a recent development. I think about it evolutionarily: if an animal was subject to significant early trauma (i.e. divergence from expected early environment), the most likely cause is early loss of a parent and no surrogate caretaker. This suggests a markedly different environment generally, and especially socially, and would warrant a significant behavior shift if it were evolutionarily possible to accomplish. It doesn’t seem so implausible to me.
- robwwilliams 3y agoYou are correct.