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Technically no it doesn't. I had thought that curing did mean fixing the problem, but I just googled and it does indeed also mean relieving of the symptoms. Bu

Technically no it doesn't. I had thought that curing did mean fixing the problem, but I just googled and it does indeed also mean relieving of the symptoms. But I think in this case they're right to clarify. I think the low level of common knowledge around gene editing could lead people to believe that this is mutating the sickle cells into healthy cells, which it isn't doing

WhitneyLand 3y ago
It might clarify how it actually works, but he’s saying it’s not a cure, and if that’s not factually correct that’s not a good thing.
thaumasiotes 3y ago
> I had thought that curing did mean fixing the problem, but I just googled and it does indeed also mean relieving of the symptoms. Usually curing would mean fixing the problem, or more specifically it would mean permanently eliminating the symptoms. This contrasts with "treatment" temporarily relieving the symptoms. https://my.clevelandclinic.org/health/articles/24434-cure https://my.clevelandclinic.org/health/articles/24434-cure > Being cured of a disease means it’s completely gone and isn’t coming back. For many people, cures represent the ultimate treatment goal. Most diseases and conditions aren’t curable. (This link disagrees with my use of "treatment", saying that "treatment" is any procedure, and "cure" is one of many possible outcomes of a treatment, with temporary relief being another possible outcome. But the point stands that curing definitely does mean fixing the problem.) Glasses do not cure myopia, but they are so effective at relieving the symptoms, in an inexpensive and noninvasive way, that there is no real need for a cure.
- WhitneyLand 3y ago
  >Usually curing would mean fixing the problem No, I believe you’re thinking of “problem” in a different way. A cure permanently relieves symptoms of a disease. The symptoms are what’s “gone and is never coming back.” That much alone is called a “functional cure”, it’s not just a treatment. The difference between a cure and a functional cure depends on the disease but in either case, it means it’s not coming back.
  - thaumasiotes 3y ago
    > No, I believe you’re thinking of “problem” in a different way. > A cure permanently relieves symptoms of a disease. This is a surreal correction for you to make after selectively quoting the first half of my sentence. Let's look at the whole thing: >> Usually curing would mean fixing the problem, or more specifically it would mean permanently eliminating the symptoms. Did you have something to add to that?
raducu 3y ago
> but I just googled and it does indeed also mean relieving of the symptoms. In that sense AIDS is also cured, but in my book it's not, because people with it have to take pills for the rest of their lives and those pills do have serious side effects.
- WhitneyLand 3y ago
  The definition relates to a treatment not the disease. In your example the question would be, does antiretroviral therapy cure HIV? It does reduce the viral load but not permanently, so no, its not considered a cure. The answer might change with the treatment. Does a stem cell bone marrow transplant eliminate HIV? Yes, permanently as far as it’s known so HIV is “cured” in this case.
- ChrisRR 3y ago
  That agrees with the point I was making. They are clarifying that this doesn't make the disease go away, but it sufficiently treats it to the point where it would have little to no effect. So it's a cure for some definitions of cure, but not all

WhitneyLand 3y ago

It might clarify how it actually works, but he’s saying it’s not a cure, and if that’s not factually correct that’s not a good thing.

thaumasiotes 3y ago

> I had thought that curing did mean fixing the problem, but I just googled and it does indeed also mean relieving of the symptoms. Usually curing would mean fixing the problem, or more specifically it would mean permanently eliminating the symptoms. This contrasts with "treatment" temporarily relieving the symptoms. https://my.clevelandclinic.org/health/articles/24434-cure https://my.clevelandclinic.org/health/articles/24434-cure > Being cured of a disease means it’s completely gone and isn’t coming back. For many people, cures represent the ultimate treatment goal. Most diseases and conditions aren’t curable. (This link disagrees with my use of "treatment", saying that "treatment" is any procedure, and "cure" is one of many possible outcomes of a treatment, with temporary relief being another possible outcome. But the point stands that curing definitely does mean fixing the problem.) Glasses do not cure myopia, but they are so effective at relieving the symptoms, in an inexpensive and noninvasive way, that there is no real need for a cure.

WhitneyLand 3y ago
>Usually curing would mean fixing the problem No, I believe you’re thinking of “problem” in a different way. A cure permanently relieves symptoms of a disease. The symptoms are what’s “gone and is never coming back.” That much alone is called a “functional cure”, it’s not just a treatment. The difference between a cure and a functional cure depends on the disease but in either case, it means it’s not coming back.
- thaumasiotes 3y ago
  > No, I believe you’re thinking of “problem” in a different way. > A cure permanently relieves symptoms of a disease. This is a surreal correction for you to make after selectively quoting the first half of my sentence. Let's look at the whole thing: >> Usually curing would mean fixing the problem, or more specifically it would mean permanently eliminating the symptoms. Did you have something to add to that?

raducu 3y ago

> but I just googled and it does indeed also mean relieving of the symptoms. In that sense AIDS is also cured, but in my book it's not, because people with it have to take pills for the rest of their lives and those pills do have serious side effects.

WhitneyLand 3y ago
The definition relates to a treatment not the disease. In your example the question would be, does antiretroviral therapy cure HIV? It does reduce the viral load but not permanently, so no, its not considered a cure. The answer might change with the treatment. Does a stem cell bone marrow transplant eliminate HIV? Yes, permanently as far as it’s known so HIV is “cured” in this case.
ChrisRR 3y ago
That agrees with the point I was making. They are clarifying that this doesn't make the disease go away, but it sufficiently treats it to the point where it would have little to no effect. So it's a cure for some definitions of cure, but not all