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For what it’s worth my grandfather researched sickle cell and found that l-citrulline supplementation greatly improves quality of life for people with sickle ce

For what it’s worth my grandfather researched sickle cell and found that l-citrulline supplementation greatly improves quality of life for people with sickle cell. Unfortunately sports supplementation and erectile dysfunction treatment was the more lucrative of his patents and he died before he could finish FDA approval work for treatment of sickle cell anemia (not a cure). As citrulline isn’t expensive no one was willing to pick up his research. He provided citrulline to his patients throughout his life as their quality of life improved dramatically as to be entirely normal. I don’t know that anyone kept track of them after his death, but his research into citrulline for other purposes such as erectile and exercise performance ensured that it’s widely available now. https://thescholarship.ecu.edu/handle/10342/3137 https://thescholarship.ecu.edu/handle/10342/3137 You can purchase it from many places but this manufacturer has a good reputation: BULKSUPPLEMENTS.COM L-Citrulline Malate 2:1 Powder - L Citrulline Malate Supplement, Citrulline Malate Powder - Unflavored & Gluten Free - 3g per Servings, 333 Servings, 1kg (2.2 lbs) https://a.co/d/fzNovRX https://a.co/d/fzNovRX Citrulline is extremely safe in any quantity. Any excess is urinated out.

WhitneyLand 3y ago
I think people are downvoting your answer incorrectly. Best I can tell that’s because you used the word SUPPLEMENTS in all caps which is reminiscent of spam email. However, while I can’t validate anything about your grandfather what you’re saying seems plausible and some papers have talked about it. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2594068 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2594068
- fnordpiglet 3y ago
  Perhaps! That’s just the auto formatted text from an Amazon share link on iOS - no referral code in the link! His patents were exhaustively written and documented in medical textbook style (rather than legal robot style) further detailing the variety of uses of citrulline: https://patents.google.com/patent/US5874471A/en https://patents.google.com/patent/US5874471A/en The essence is arginine is crucial in the production of NO, which serves many functions of the body but it’s also a powerful vasoprotector. Sickle cell is popularly thought to cause anemia due to the cell shape not carrying enough oxygen, but in fact it’s due to the shape irritating the epithelial cells lining blood vessels, particularly small vessels and capillaries. This redirects the use of arginine in the body to repairing and protecting the blood vessels in the body. Citrulline is an intermediate non essential amino acid found in high concentration in watermelon seeds (hence the name). It survives the gut, unlike direct arginine ingestion, and converts readily to arginine in the kidneys (my grandfather was an expert in kidney function and pioneered kidney transplants in the 1950’s and 1969’s, his interest in sickle came late in his career in the 1990’s). He was also an expert in heart disease, and as a young man was a tenured professor of medicine at University of Kentucky, chair of cardiovascular research, and an endowed member of the Kentucky Heart Association. He left Kentucky to found the first regional hospital and medical school in eastern North Carolina, ECU, where he was the director for many years. He was a terror of grad students, never accepted outside grant money for any of his research, never worked with drug companies, and led the bioethical research boards at his medical school for most of his career. He earned the nickname Dr House for his remarkable ability to diagnose obscure diseases and conditions along with novel treatments using his encyclopedic knowledge of biochemistry and disease, as well as his often obnoxious personality. The university forced him to retire because he brought no funding and had an entire floor for his lab when he was in his late 70’s, so he tore out his garage and built a laboratory in its place where he spent the rest of his years self publishing new research. https://www.legacy.com/us/obituaries/reflector/name/william-waugh-obituary?id=21549647 https://www.legacy.com/us/obituaries/reflector/name/william-...

WhitneyLand 3y ago

I think people are downvoting your answer incorrectly. Best I can tell that’s because you used the word SUPPLEMENTS in all caps which is reminiscent of spam email. However, while I can’t validate anything about your grandfather what you’re saying seems plausible and some papers have talked about it. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2594068 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2594068

fnordpiglet 3y ago
Perhaps! That’s just the auto formatted text from an Amazon share link on iOS - no referral code in the link! His patents were exhaustively written and documented in medical textbook style (rather than legal robot style) further detailing the variety of uses of citrulline: https://patents.google.com/patent/US5874471A/en https://patents.google.com/patent/US5874471A/en The essence is arginine is crucial in the production of NO, which serves many functions of the body but it’s also a powerful vasoprotector. Sickle cell is popularly thought to cause anemia due to the cell shape not carrying enough oxygen, but in fact it’s due to the shape irritating the epithelial cells lining blood vessels, particularly small vessels and capillaries. This redirects the use of arginine in the body to repairing and protecting the blood vessels in the body. Citrulline is an intermediate non essential amino acid found in high concentration in watermelon seeds (hence the name). It survives the gut, unlike direct arginine ingestion, and converts readily to arginine in the kidneys (my grandfather was an expert in kidney function and pioneered kidney transplants in the 1950’s and 1969’s, his interest in sickle came late in his career in the 1990’s). He was also an expert in heart disease, and as a young man was a tenured professor of medicine at University of Kentucky, chair of cardiovascular research, and an endowed member of the Kentucky Heart Association. He left Kentucky to found the first regional hospital and medical school in eastern North Carolina, ECU, where he was the director for many years. He was a terror of grad students, never accepted outside grant money for any of his research, never worked with drug companies, and led the bioethical research boards at his medical school for most of his career. He earned the nickname Dr House for his remarkable ability to diagnose obscure diseases and conditions along with novel treatments using his encyclopedic knowledge of biochemistry and disease, as well as his often obnoxious personality. The university forced him to retire because he brought no funding and had an entire floor for his lab when he was in his late 70’s, so he tore out his garage and built a laboratory in its place where he spent the rest of his years self publishing new research. https://www.legacy.com/us/obituaries/reflector/name/william-waugh-obituary?id=21549647 https://www.legacy.com/us/obituaries/reflector/name/william-...