4 ms·

Isn't lethality the strongest psychoactive effect? It's a decent measure for how much a certain amount of a drug is likely to cause immediate important effects

Isn't lethality the strongest psychoactive effect? It's a decent measure for how much a certain amount of a drug is likely to cause immediate important effects in the body.

tambourine_man 3y ago
It’s not. There’s no known lethal dose for LSD, for instance. And it takes only a few grams to have incredibly potent psychoactive effect
- someplaceguy 3y ago
  The estimated average lethal dose for LSD in humans is only 100 mg, based on rodent studies. Far less than caffeine and even amphetamines. LSD does cause significant psychoactive effects with one thousandth of that amount, which suggests that for a typical isolated dose, LSD is safer than caffeine and amphetamines. Not to mention that LSD is not as addictive. But I don't think that invalidates my underlying point regarding caffeine, even if the lethal dose is not a perfect measure.
  - tambourine_man 3y ago
    There’s no correlation between lethality and psychoactive strength and you’re trying to make a point based on it.
    - someplaceguy 3y ago
      > There’s no correlation between lethality and psychoactive strength and you’re trying to make a point based on it. Of course there is, and it's obviously a positive correlation. I think you just proved you don't understand what a correlation is...
      - tambourine_man 3y ago
        Here’s Wikipedia article for one of the most powerful psychoactive substances known to man: “Overdose: There have been no documented fatal human overdoses from LSD” https://en.m.wikipedia.org/wiki/LSD https://en.m.wikipedia.org/wiki/LSD Toxicity and psychoactivity are completely independent from one another. If you can’t understand that there’s not much else I can say to you.
        deleted 3y ago
        [deleted]
      - dang 3y ago
        Could you please stop posting in the flamewar style and/or otherwise breaking the site guidelines? You've unfortunately been doing it repeatedly. It's not what this site is for, and destroys what it is for. If you wouldn't mind reviewing https://news.ycombinator.com/newsguidelines.html https://news.ycombinator.com/newsguidelines.html and taking the intended spirit of the site more to heart, we'd be grateful.
        deleted 3y ago
        [deleted]

Isn't lethality the strongest psychoactive effect? It's a decent measure for how much a certain amount of a drug is likely to cause immediate important effects in the body.

tambourine_man 3y ago

It’s not. There’s no known lethal dose for LSD, for instance. And it takes only a few grams to have incredibly potent psychoactive effect

someplaceguy 3y ago
The estimated average lethal dose for LSD in humans is only 100 mg, based on rodent studies. Far less than caffeine and even amphetamines. LSD does cause significant psychoactive effects with one thousandth of that amount, which suggests that for a typical isolated dose, LSD is safer than caffeine and amphetamines. Not to mention that LSD is not as addictive. But I don't think that invalidates my underlying point regarding caffeine, even if the lethal dose is not a perfect measure.
- tambourine_man 3y ago
  There’s no correlation between lethality and psychoactive strength and you’re trying to make a point based on it.
  - someplaceguy 3y ago
    > There’s no correlation between lethality and psychoactive strength and you’re trying to make a point based on it. Of course there is, and it's obviously a positive correlation. I think you just proved you don't understand what a correlation is...
    - tambourine_man 3y ago
      Here’s Wikipedia article for one of the most powerful psychoactive substances known to man: “Overdose: There have been no documented fatal human overdoses from LSD” https://en.m.wikipedia.org/wiki/LSD https://en.m.wikipedia.org/wiki/LSD Toxicity and psychoactivity are completely independent from one another. If you can’t understand that there’s not much else I can say to you.
      - deleted 3y ago
        [deleted]
    - dang 3y ago
      Could you please stop posting in the flamewar style and/or otherwise breaking the site guidelines? You've unfortunately been doing it repeatedly. It's not what this site is for, and destroys what it is for. If you wouldn't mind reviewing https://news.ycombinator.com/newsguidelines.html https://news.ycombinator.com/newsguidelines.html and taking the intended spirit of the site more to heart, we'd be grateful.
      - deleted 3y ago
        [deleted]