3 ms·
This study is about the amphetamine stimulants methylphenidate, dextroamphetamine, and the eugeroic (wakefulness agent) modafinil, and not about nootropics. Tho
by matznerd 3y ago
This study is about the amphetamine stimulants methylphenidate, dextroamphetamine, and the eugeroic (wakefulness agent) modafinil, and not about nootropics. Though the term smart drug can be inclusive of all of them...
Real smart drugs = nootropics = piracetam and piracetam-like molecules. Stimulants generally decrease performance, increase false positives, and lead to worse performance as this study showed (especially in a first time user).
Most nootropics take about 14 days to hit their stride and the effect isn't discernible immediately (though can be detected in an EEG)...
See study: "Increase in the power of human memory in normal man through the use of drugs"
"Nootropyl (Piracetam) a drug reported to facilitate learning in animals was tested for its effect on man by administering it to normal volunteers. The subjects were given 3x4 capsules at 400 mg per day, in a double blind study. Each subject learned series of words presented as stimuli upon a memory drum. No effects were observed after 7 days but after 14 days verbal learning had significantly increased."
https://pubmed.ncbi.nlm.nih.gov/826948/ https://pubmed.ncbi.nlm.nih.gov/826948/
Study: "Single-dose piracetam effects on global complexity measures of human spontaneous multichannel EEG"
"The results indicate that a single dose of piracetam dose-dependently affects the spontaneous EEG in normal volunteers, showing effects at the lowest treatment level. The decreased EEG complexity is interpreted as increased cooperativity of brain functional processes."
https://pubmed.ncbi.nlm.nih.gov/10555876/ https://pubmed.ncbi.nlm.nih.gov/10555876/
Study: "Single doses of piracetam affect 42-channel event-related potential microstate maps in a cognitive paradigm"
"U-shaped dose-dependent effects were found; they were strongest after 4.8 g piracetam. Since these particular ERP segments are recognized to be strongly correlated to cognitive functions, the present findings suggest that single medium doses of piracetam selectively activate differently located or oriented neurons during cognitive steps of information processing."
https://pubmed.ncbi.nlm.nih.gov/8272204/ https://pubmed.ncbi.nlm.nih.gov/8272204/
- scythe 3y agoThe authors are rather unfair to modafinil, also, lumping it in with the other two even though the negative "effects" of modafinil were not statistically significant (except in the rather dubious case of the rank testing of "productivity deviations") and the mean deviation was very small. Also, the "value attained" is not available for modafinil specifically; for this criterion — which is the most believable, as it measures what participants actually tried to achieve — the drugs are all counted together, while on other measures they are listed separately. This is particularly disconcerting since the total value attained makes its way into the abstract and the press release yet gets shorted on the analysis.
- cvdub 3y agoIs piracetam still the goto for the nootropics community? I thought people were moving away from that for some reason, but I can’t remember why or where I heard that.
- Sander3Utile 3y agoNoopept is a potential candidate for another replacement. It’s basically has a similar safety profile but it’s more potent and requires much less to achieve the desired effect.
- AstralStorm 3y agoNoopept is essentially a peptide chemical mimic. Price wise Piracetam is cheaper and easier to make. Metabolism is similar enough, potency while higher likewise runs into the same side effect profile at too high dosage so is no good. Noopept should be a bit lighter on the liver and kidneys.
- Solortho 3y agoAbout nootropics, I really enjoy noopept, it allows me to perform long and focused session of work without any side effect.