3 ms·

> I am doubtful of the optic nerve regeneration because of the absolutely insane density of the nerve fiber. Seems like something that will be beyond the grasp

> I am doubtful of the optic nerve regeneration because of the absolutely insane density of the nerve fiber. Seems like something that will be beyond the grasp of science for the foreseeable future It's been done quite successfully in mice [0]. Last I checked, it was being tested on primates. The method relies on activating the Yamanaka factors used in stem cell research. [0] https://hms.harvard.edu/news/vision-revision https://hms.harvard.edu/news/vision-revision

jessriedel 3y ago
Your link is about gene therapy in the eyes of mice, and is specifically a method designed as an alternative to transplant: > “This new approach, which successfully reverses multiple causes of vision loss in mice without the need for a retinal transplant, represents a new treatment modality in regenerative medicine.” And that's just retinal transplant, much less whole-eye transplant.
- david-gpu 3y ago
  The link provided is also about about a method to produce optic nerve regeneration, regardless of whether there has been a transplant or not. Unless you have a reason to believe that it would not work in the case of a transplant.
  - westurner 3y ago
    Retina or optic nerve: how do the regenerative methods differ? Visual system > System overview: https://en.wikipedia.org/wiki/Visual_system https://en.wikipedia.org/wiki/Visual_system : > Mechanical: Together, the cornea and lens refract light into a small image and shine it on the retina. The retina transduces this image into electrical pulses using rods and cones. The optic nerve then carries these pulses through the optic canal. Upon reaching the optic chiasm the nerve fibers decussate (left becomes right). The fibers then branch and terminate in three places. [1][2][3][4][5][6][7] >Neural: Most of the optic nerve fibers end in the lateral geniculate nucleus (LGN). https://news.ycombinator.com/item?id=36912925 https://news.ycombinator.com/item?id=36912925 , ... : - "Direct neuronal reprogramming by temporal identity factors" (2023) https://www.pnas.org/doi/10.1073/pnas.2122168120#abstract https://www.pnas.org/doi/10.1073/pnas.2122168120#abstract - "Retinoid therapy restores eye-specific cortical responses in adult mice with retinal degeneration" (2022) https://www.cell.com/current-biology/fulltext/S0960-9822(22)01449-X https://www.cell.com/current-biology/fulltext/S0960-9822(22)... - "Genetic and epigenetic regulators of retinal Müller glial cell reprogramming" (2023) https://www.sciencedirect.com/science/article/pii/S2667376223000173 https://www.sciencedirect.com/science/article/pii/S266737622... - https://en.wikipedia.org/wiki/Tissue_nanotransfection#Technique https://en.wikipedia.org/wiki/Tissue_nanotransfection#Techni... Ctrl-F "neurons" Regeneration in humans > Induced regeneration: https://en.wikipedia.org/wiki/Regeneration_in_humans#Induced_regeneration https://en.wikipedia.org/wiki/Regeneration_in_humans#Induced...
  - jessriedel 3y ago
    I absolutely have a reason to think optic nerve regeneration will be less effective in a transplant. In a transplant, the nerve has been severed!

jessriedel 3y ago

Your link is about gene therapy in the eyes of mice, and is specifically a method designed as an alternative to transplant: > “This new approach, which successfully reverses multiple causes of vision loss in mice without the need for a retinal transplant, represents a new treatment modality in regenerative medicine.” And that's just retinal transplant, much less whole-eye transplant.

david-gpu 3y ago
The link provided is also about about a method to produce optic nerve regeneration, regardless of whether there has been a transplant or not. Unless you have a reason to believe that it would not work in the case of a transplant.
- westurner 3y ago
  Retina or optic nerve: how do the regenerative methods differ? Visual system > System overview: https://en.wikipedia.org/wiki/Visual_system https://en.wikipedia.org/wiki/Visual_system : > Mechanical: Together, the cornea and lens refract light into a small image and shine it on the retina. The retina transduces this image into electrical pulses using rods and cones. The optic nerve then carries these pulses through the optic canal. Upon reaching the optic chiasm the nerve fibers decussate (left becomes right). The fibers then branch and terminate in three places. [1][2][3][4][5][6][7] >Neural: Most of the optic nerve fibers end in the lateral geniculate nucleus (LGN). https://news.ycombinator.com/item?id=36912925 https://news.ycombinator.com/item?id=36912925 , ... : - "Direct neuronal reprogramming by temporal identity factors" (2023) https://www.pnas.org/doi/10.1073/pnas.2122168120#abstract https://www.pnas.org/doi/10.1073/pnas.2122168120#abstract - "Retinoid therapy restores eye-specific cortical responses in adult mice with retinal degeneration" (2022) https://www.cell.com/current-biology/fulltext/S0960-9822(22)01449-X https://www.cell.com/current-biology/fulltext/S0960-9822(22)... - "Genetic and epigenetic regulators of retinal Müller glial cell reprogramming" (2023) https://www.sciencedirect.com/science/article/pii/S2667376223000173 https://www.sciencedirect.com/science/article/pii/S266737622... - https://en.wikipedia.org/wiki/Tissue_nanotransfection#Technique https://en.wikipedia.org/wiki/Tissue_nanotransfection#Techni... Ctrl-F "neurons" Regeneration in humans > Induced regeneration: https://en.wikipedia.org/wiki/Regeneration_in_humans#Induced_regeneration https://en.wikipedia.org/wiki/Regeneration_in_humans#Induced...
- jessriedel 3y ago
  I absolutely have a reason to think optic nerve regeneration will be less effective in a transplant. In a transplant, the nerve has been severed!