+1 for Pylons. We're currently serving around 20 million dynamic requests a day via pylons from a handful of servers; pylons probably won't be your bottleneck.

+1 for Pylons. We're currently serving around 20 million dynamic requests a day via pylons from a handful of servers; pylons probably won't be your bottleneck. What I like about it: python, promotes good code organization, relatively small code base (you can just read the source code if you're not sure how something works), and for the most part it stays out of your way.