5 ms·

https://sci-hub.hkvisa.net/10.1016/j.mehy.2013.11.018 https://sci-hub.hkvisa.net/10.1016/j.mehy.2013.11.018 While it discusses multi-year treatment, the paper

https://sci-hub.hkvisa.net/10.1016/j.mehy.2013.11.018 https://sci-hub.hkvisa.net/10.1016/j.mehy.2013.11.018 While it discusses multi-year treatment, the paper says "After several weeks of such treatment the pattern of behavior in ADHD patients is normalized." which feels like something that could be easily tried out. Since it was published in 2013 I'd expect some follow-up? (checking for citations now) Edit: Sadly, "No Tryptophan, Tyrosine and Phenylalanine Abnormalities in Children with Attention-Deficit/Hyperactivity Disorder" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777504/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777504/ 2016, larger study. (although they measure the amounts rather than ratios, so not exactly the same idea)

Podgajski 3y ago
Nutritional studies are hard to get funding for in the first place, never mind the follow-ups. They found nothing in the study, because IMI they were measuring the wrong neurotransmitters. Dopamine is not the cause of the symptoms. It has to do with glutamate and GABA Balance. Since stimulants can control effect glutamate and GABA as well as Dopamine , that’s why there is all the confusion. B6 also plays a role in glutamate GABA balance through stimulating the glutamate dehydrogenase enzyme. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5545734/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5545734/
- viraptor 3y ago
  It looks like you have a whole stash of related papers. If you could send all those links, I'd really appreciate it.
  - Podgajski 3y ago
    They all stashed my brain after years of researching nutritional psychiatry. As far as ADHD goes, I just suggest searching both PubMed and Google scholar for ADHD, glutamate and GABA. I think glutamate and GABA play a larger, or fundenental role, in most psychiatric disorders.
    - InSteady 3y ago
      May be a part of why so many people with psychiatric disorders (especially undiagnosed or untreated) often use nicotine and/or alcohol to cope. They both interact heavily with the GABAergic system. Alcohol also inhibits the activity of glutamate and reduces extracellular levels in certain brain regions. Too much glutamate in the brain can cause 'failure of different neurotransmission systems' and is neurotoxic. It's too bad self-medicating with these substances comes with such awful downsides.
      - Podgajski 3y ago
        Ethanol is my go to medication. It’s the only calcium, sodium, and potassium ion channel blocker that can enter the brain. These are implicated in bipolar disorder which I have. The trick is to not abuse it just like any other medication. I also have labile hypertension and it’s the only medication I can take that controls my blood pressure spikes. I feel the same way about nicotine, although I can’t take it because it turns me to up. Nicotine is a stimulant and can be used as a medicine in lower doses. The problem is that people used to do and that sets up the addiction cycle. I definitely have an issue with a very high glutamate/GABA ratio. My other go to medicine is Klonopin which I use only when I’m in a severe crisis. Like when I had a delusional psychosis when I had Covid.

Podgajski 3y ago

Nutritional studies are hard to get funding for in the first place, never mind the follow-ups. They found nothing in the study, because IMI they were measuring the wrong neurotransmitters. Dopamine is not the cause of the symptoms. It has to do with glutamate and GABA Balance. Since stimulants can control effect glutamate and GABA as well as Dopamine , that’s why there is all the confusion. B6 also plays a role in glutamate GABA balance through stimulating the glutamate dehydrogenase enzyme. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5545734/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5545734/

viraptor 3y ago
It looks like you have a whole stash of related papers. If you could send all those links, I'd really appreciate it.
- Podgajski 3y ago
  They all stashed my brain after years of researching nutritional psychiatry. As far as ADHD goes, I just suggest searching both PubMed and Google scholar for ADHD, glutamate and GABA. I think glutamate and GABA play a larger, or fundenental role, in most psychiatric disorders.
  - InSteady 3y ago
    May be a part of why so many people with psychiatric disorders (especially undiagnosed or untreated) often use nicotine and/or alcohol to cope. They both interact heavily with the GABAergic system. Alcohol also inhibits the activity of glutamate and reduces extracellular levels in certain brain regions. Too much glutamate in the brain can cause 'failure of different neurotransmission systems' and is neurotoxic. It's too bad self-medicating with these substances comes with such awful downsides.
    - Podgajski 3y ago
      Ethanol is my go to medication. It’s the only calcium, sodium, and potassium ion channel blocker that can enter the brain. These are implicated in bipolar disorder which I have. The trick is to not abuse it just like any other medication. I also have labile hypertension and it’s the only medication I can take that controls my blood pressure spikes. I feel the same way about nicotine, although I can’t take it because it turns me to up. Nicotine is a stimulant and can be used as a medicine in lower doses. The problem is that people used to do and that sets up the addiction cycle. I definitely have an issue with a very high glutamate/GABA ratio. My other go to medicine is Klonopin which I use only when I’m in a severe crisis. Like when I had a delusional psychosis when I had Covid.