If you're looking for flexibility, give Pylons a shot. It's often paired with SQLAlchemy, which is an amazing ORM that can be configured to do a lot of things w

If you're looking for flexibility, give Pylons a shot. It's often paired with SQLAlchemy, which is an amazing ORM that can be configured to do a lot of things which will make scaling easier in the long run. (Whereas Django doesn't have multiple database support, for instance; SQLAlchemy can even handle sharded data transparently.)