tl;dr: - Open-source, portable, updated, default choice: .NET Core 1 2 3, .NET 5/6/7/8 - Included with Windows or Unity, frozen in time: .NET Framework 4 (don'

tl;dr: - Open-source, portable, updated, default choice: .NET Core 1 2 3, .NET 5/6/7/8 - Included with Windows or Unity, frozen in time: .NET Framework 4 (don't use anything older) - Want to support both: .NET Standard (this is a subset that both can run)