"So “single antibiotics don’t work for chronic Lyme but cocktails do and this wasn’t realized for decades” isn’t an unprecedented story. It could turn out that

"So “single antibiotics don’t work for chronic Lyme but cocktails do and this wasn’t realized for decades” isn’t an unprecedented story. It could turn out that way." ...this leaves me extremely skeptical of the author's argument for this. Also, properly, multi-drug therapy for HIV is less "More Dakka" in the way of some other examples, and more "Different Dakka". Massive doses of any given antiretroviral don't solve your problem. "This didn't work, have we tried more of a drug, or just more drugs" are two different treatment approaches.