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Does anyone know a good general audience book on proteomics? It seems to be a very interesting field with a bright future but I can never find the time to dig d

by pfd1986 3y ago

Does anyone know a good general audience book on proteomics? It seems to be a very interesting field with a bright future but I can never find the time to dig deep

deng 3y ago
It really depends on your prior knowledge and what aspect of proteomics you are most interested in. A good starting point is here: https://proteomicsnews.blogspot.com/p/resources-for-newbies.html https://proteomicsnews.blogspot.com/p/resources-for-newbies.... Also, if you haven't already, maybe take a look at transcriptomics first, as there's more introductory material on this topic. For instance, there's an excellent online course at https://diytranscriptomics.com/ https://diytranscriptomics.com/.
pfd1986 3y ago
Actually, to answer my own question, this seems like a good intro article: https://erictopol.substack.com/p/spatial-biology-is-lighting-it-up https://erictopol.substack.com/p/spatial-biology-is-lighting...
jszymborski 3y ago
IMHO, most fields in biology lack good on ramps when compared to CS. I think part of the reason is that it's way easier to get someone to install Python than to get access to a mass spectrometer. A big factor in me studying Biochemistry in undergrad was that it was way easier to self-teach myself the parts of CS that interested me than it was for Biochemistry, in my estimation. I'm sorry I don't have a better answer for you, I hope someone else here does!
- maegul 3y ago
  My experience in grad school was similar. IMO it decelerates the shift from undergrad to grad work, as you have to overcome the knowledge gulf by immersing yourself in the essentially confusing sea of primary literature. Arguably unnecessary IMO … good material at various levels of expertise makes a lot of sense.
getoffmycase 3y ago
There is nothing that I can think of. The tools of the trade are mass spectrometers, most dominantly right now the high end Orbitraps and the TIMS-TOF. If you’re interested in instrumentation I can send you some resources. There’s a few good reviews I can send you if you’re interested. Let me know, I’d be happy to connect.
- pfd1986 3y ago
  Thanks. I have a physics background and actually work on the medical imaging side of pharma now. But while I might be able to understand the technicalities, I guess what I'm looking for is something that explains (without much hype) what the excitement and challenges are. For instance, for my field, a great broad intro is Eric Topol's Deep Medicine https://a.co/d/242xgSC https://a.co/d/242xgSC

Does anyone know a good general audience book on proteomics? It seems to be a very interesting field with a bright future but I can never find the time to dig deep

deng 3y ago

It really depends on your prior knowledge and what aspect of proteomics you are most interested in. A good starting point is here: https://proteomicsnews.blogspot.com/p/resources-for-newbies.html https://proteomicsnews.blogspot.com/p/resources-for-newbies.... Also, if you haven't already, maybe take a look at transcriptomics first, as there's more introductory material on this topic. For instance, there's an excellent online course at https://diytranscriptomics.com/ https://diytranscriptomics.com/.

pfd1986 3y ago

Actually, to answer my own question, this seems like a good intro article: https://erictopol.substack.com/p/spatial-biology-is-lighting-it-up https://erictopol.substack.com/p/spatial-biology-is-lighting...

jszymborski 3y ago

IMHO, most fields in biology lack good on ramps when compared to CS. I think part of the reason is that it's way easier to get someone to install Python than to get access to a mass spectrometer. A big factor in me studying Biochemistry in undergrad was that it was way easier to self-teach myself the parts of CS that interested me than it was for Biochemistry, in my estimation. I'm sorry I don't have a better answer for you, I hope someone else here does!

maegul 3y ago
My experience in grad school was similar. IMO it decelerates the shift from undergrad to grad work, as you have to overcome the knowledge gulf by immersing yourself in the essentially confusing sea of primary literature. Arguably unnecessary IMO … good material at various levels of expertise makes a lot of sense.

getoffmycase 3y ago

There is nothing that I can think of. The tools of the trade are mass spectrometers, most dominantly right now the high end Orbitraps and the TIMS-TOF. If you’re interested in instrumentation I can send you some resources. There’s a few good reviews I can send you if you’re interested. Let me know, I’d be happy to connect.

pfd1986 3y ago
Thanks. I have a physics background and actually work on the medical imaging side of pharma now. But while I might be able to understand the technicalities, I guess what I'm looking for is something that explains (without much hype) what the excitement and challenges are. For instance, for my field, a great broad intro is Eric Topol's Deep Medicine https://a.co/d/242xgSC https://a.co/d/242xgSC