I've quit both cigarettes and a middling amphetamines addiction. Quitting cigarettes was trivial. I decided not to buy a pack that day and then never bought an

I've quit both cigarettes and a middling amphetamines addiction. Quitting cigarettes was trivial. I decided not to buy a pack that day and then never bought another pack. That's my anecdotal contribution to the discussion. Less anecdotally: Opioid withdrawal, in extreme cases, has killed people from persistent vomiting and diarrhea. It has measurable physical symptoms with an understood pathophysiology largely connected to the cAMP-signaling system. Nicotine withdrawal is far less understood, to the degree it has been classified at all (mostly in studies of mice). It certainly has never killed anyone, you're not going to shit yourself to death. They're not comparable to one another.