2 ms·
I can't speak to chiral gold, but as for exploring the connection between microbiota and neurodegenerative diseases, this is a hot area of study. Take a sentenc
by InSteady 3y ago
I can't speak to chiral gold, but as for exploring the connection between microbiota and neurodegenerative diseases, this is a hot area of study. Take a sentence from the abstract:
>The gut–brain axis has emerged as a therapeutic target in neurodegenerative diseases by modulating metabolic activity, neuroimmune functions and sensory neuronal signaling.
You can pretty much formulate a few dozen google searches from various keywords in that sentence + "microbiome," "microbiota," and/or "GI immune signaling," etc and come up with hundreds of papers. The GI tract is host to the majority of our immune system. Many of the molecules used for signaling (and all kinds of other tasks) come directly from the bacteria there, or else are dependent on bacterial metabolites as inputs.
On a related note, I expect we will hear more about the metabolome in health and medicine research. As microbiome is the set of all microbes in the body, metabolome is the set of all metabolites (bacterial and endogenous) in the body. In this study, serum levels of an indole were found to be altered in Alzheimer's patients:
>indole-3-acetic acid, which was lower in serum and cerebrospinal fluid of patients with AD compared with age-matched controls.
In another study of MS patients, two other indoles, as well as butyrate, were found to be lower in serum concentration compared to healthy controls [1]:
>Highlights - Gut microbiota and metabolites profiles of individuals with
MS differ from healthy controls. Individuals with MS have reduced serum levels of
indolepropionate. Individuals with MS have reduced serum levels of indolelactate and its producing bacteria. Individuals with MS have lower levels of species and genes
involved in butyrate production.
Indoles in particular may be an interesting avenue of research [2]:
>What is the function of the indole in bacteria?
Indole has recently been implicated as an important small molecule signal utilized by many bacteria to coordinate various forms of behavior. Indole plays a role in numerous bacterial processes, including: biofilm formation and maintenance, virulence factor production, antibiotic resistance and persister cell formation.
[1] - https://www.cell.com/cell-reports-medicine/pdf/S2666-3791(21)00062-8.pdf https://www.cell.com/cell-reports-medicine/pdf/S2666-3791(21...
[2] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175420/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175420/