> You could give me my antidepressants while I was under and when I woke up they would still work the same because it's a physiological change. I don't like th

> You could give me my antidepressants while I was under and when I woke up they would still work the same because it's a physiological change. I don't like this description because it implies a kind of mind-body dualism. Conscious processing also induces physiological changes, they're just of a different kind than the action of antidepressants. Your conclusion is basically correct though, that the conscious experience of psychedelics must be a critical component of their effectiveness.