I think it is useful to draw a distinction between “new” nootropics and those with hundreds of years of demonstrated use. While nicotine has not historically b

I think it is useful to draw a distinction between “new” nootropics and those with hundreds of years of demonstrated use. While nicotine has not historically been used in isolation, it has been used both in recreation and religion settings for around 2000 years. Caffeine use is similar, perhaps older. There’s still reason to be wary of higher dosages or new delivery routes, but it seems unlikely that dabbling in low-dose caffeine or nicotine use will make you go crazy, based on the mountain of historical evidence to the contrary.