That's definitely an anecdote, but I think the salient point is this: > So, forgive the hesitance, but I am even more hardened on the notion that we should pro

That's definitely an anecdote, but I think the salient point is this: > So, forgive the hesitance, but I am even more hardened on the notion that we should probably not mess with our brains too much And that's true, insofar as we are able to agree on what "mess with our brains" and "too much" means. Is taking some choline "messing" with the brain? Definitely. Is it "too much?" well, perhaps you think so. Is drinking coffee "too much"? Apparently we both agree that it is not "too much", I'm drinking some caffeine right now. One thing about Choline and Caffeine is that they are very well studied, especially in terms of safety. The further you go into the nootropics world the less studied options you'll find - things range from "zero data" to "used for 1000s of years by an unscientific people" to "animal studies exist" and beyond. My personal "too much" is when there's a combination of weak evidence to support benefits and weak evidence to support safety in humans.