3 ms·
N=4, "Donostia city marathon 2022 (n=2), and the Zegama-Aizkorri mountain marathon 2023 (n=2). All of them were well-trained men aged 45-73 years old completed
by canucker2016 3y ago
N=4,
"Donostia city marathon 2022 (n=2), and the Zegama-Aizkorri mountain marathon 2023 (n=2). All of them were well-trained men aged 45-73 years old completed the marathon in a good healthy state."
mountain marathon had 5400+m of elevation gain. Yikes.
The 73 year old is doing well for his age. No idea about the mountain marathon times (unless the 73 year old ran the mountain marathon - mountain or urban, 3:45 is a good time regardless for a 73 year old)
Table S3 from paper
Runner 1 Runner 2 Runner 3 Runner 4
Age 73 59 45 46
Weight(kg) 58 76 69 71
Height(cm) 160 181 180 180
Time 3h45m 3h59m 4h40m 6h06m
HR (avg) 150 145 152 N/A
- canucker2016 3y agoNear the end of the paper: Though the risk rise (26% higher) is low in individuals with a history of vigorous physical activity, there is a five-fold mortality rate increase in professional athletes (39). Vigorous physical activity likely increases glutamate excitotoxicity and oxidative stress, hastening neurodegeneration in individuals with a genetic predisposition for the development of ALS (38). Therefore, while the impact of marathon running in well trained individuals is null, for those with ALS genetic risk, disease vulnerable motor areas are impacted more on otherwise physiological myelin expenditure (e.g., corticospinal tract), as myelin itself and myelin-producing oligodendrocytes are also vulnerable to glutamate excitotoxicity as well (40).
- w10-1 3y agoNot just ALS: glutamate excitotoxicity is one of the proposed mechanisms for progressive forms of multiple sclerosis