Bevacizumab (brand name avastin) for metastatic colorectal cancer (standard of care in the Netherlands, approved by the FDA and EMA and recommended by the conse

Bevacizumab (brand name avastin) for metastatic colorectal cancer (standard of care in the Netherlands, approved by the FDA and EMA and recommended by the consensus guidelines of ESMO https://www.esmo.org/guidelines/guidelines-by-topic/esmo-clinical-practice-guidelines-gastrointestinal-cancers/clinical-practice-guideline-metastatic-colorectal-cancer https://www.esmo.org/guidelines/guidelines-by-topic/esmo-cli...) and is a well known example. See the response of parliament to a petition to change it now that the patent has expired. NHS will still not fund it and cites cost as an important factor https://petition.parliament.uk/petitions/616742?reveal_response=yes https://petition.parliament.uk/petitions/616742?reveal_respo... . I would note that since funds are limited, any system needs some kind of cost-benefit analysis for drugs to ensure affordability of care. Making this cost-benefit analysis central, transparant, and explicit is probably the best way to do it.