That seems like a slightly different scale of simulation, though... a SC-like RTS with a few hundred units at most, vs tens of thousands of citizens in Skylines

That seems like a slightly different scale of simulation, though... a SC-like RTS with a few hundred units at most, vs tens of thousands of citizens in Skylines? I'd more compare it with something like Dyson Sphere Project, which can scale from a few factories & conveyor belts to many planets and thousands of things (resources, drones, belts, arms, whatever) on-screen at once. It's also made in Unity and has great performance and terrific graphics.