For Humans this adaptation is very localized, see https://en.wikipedia.org/wiki/ALDH2 https://en.wikipedia.org/wiki/ALDH2 Lots of people have less of that ALDH

For Humans this adaptation is very localized, see https://en.wikipedia.org/wiki/ALDH2 https://en.wikipedia.org/wiki/ALDH2 Lots of people have less of that ALDH2 gene, so a much smaller dose will be enough to get them drunk.