3 ms·
As a layman, I find this extremely enlightening. Even now, (anecdotally) a lot/most people describe it as primarily a respiratory disease. From the OP article:
by karim79 3y ago
As a layman, I find this extremely enlightening. Even now, (anecdotally) a lot/most people describe it as primarily a respiratory disease.
From the OP article:
> "Using nasal swabs and autopsy tissues from affected patients and animal models, researchers found that the virus blocks specific genes that use oxygen to create ATP, forcing the body to deplete finite energy reserves in the body. Without an energy source, cells throughout the body begin to starve, with the cells powering the brain and the heart suffering the most."
This is the first thing I've read which actually makes bloody sense.
A 2020 study linked below:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7443557/#:~:text=Of%20the%2084%20COVID%2D19,73.3%25%2C%20respectively)%2C%20circulatory https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7443557/#:~:tex...
From the aforementioned 2020 study:
"Of the 84 COVID-19 cases with known direct cause of death, the top 3 common direct causes of death were multiple organ failure (67.9%), circulatory failure (20.2%), and respiratory failure (11.9%), and were similar (P = 0.50) for males and females: multiple organ failure (64.8% vs 73.3%, respectively), circulatory failure (24.1% vs 13.4%, respectively), and respiratory failure (11.1% vs 13.3%, respectively)."
- irdc 3y ago>> "Using nasal swabs and autopsy tissues from affected patients and animal models, researchers found that the virus blocks specific genes that use oxygen to create ATP (…) Without an energy source, cells throughout the body begin to starve, with the cells powering the brain and the heart suffering the most." There is some weird reasoning going on here, as neuronal cells are famous for being powered anaerobically using glucose and/or ketones.
- garganzol 3y ago> neuronal cells are famous for being powered anaerobically Neurons are among the most energy-demanding cells in the body, they die the first without oxygen. Then come muscles (including heart) and liver. This means that all those cells are mostly aerobic, and only slightly anaerobic. It is true that all human body cells have an anaerobic metabolic pathway as well, but it is inefficient and cannot satisfy the energy demands for a human body to stay alive for too long without the oxygen supply.
- mpreda 3y ago> as neuronal cells are famous for being powered anaerobically using glucose and/or ketones Neurons are not famous for being powered anaerobically; if anything, they're famous for being powered exclusivelly-aerobic. AFAIK, the neurons are dependent on oxygen, thus aerobic. And unless I'm wrong, the ketones for energy is also an aerobic process. The place where we normally find anaerobic metabolism is in muscles, which are able to produce ATP using glucose to lactic acid without oxygen.
- deleted 3y ago[deleted]