I agree with your perspective, but would add a little nuance. I think the molecularly-mediated version of genetics is promising (e.g., Transcriptome Wide Associ

I agree with your perspective, but would add a little nuance. I think the molecularly-mediated version of genetics is promising (e.g., Transcriptome Wide Association Studies, or TWAS). It breaks out of the black box a little, but still enriches for causal associations that purely mechanistic approaches miss. Pure molecular mechanism has a hard time tracing from cells to organismal phenotype at age 60 in a varied environment.