3 ms·
> The real sci-fi moment will be when they get to the point they can treat in a day. How do you imagine that would work? Some closed-pipeline machine that liv
by derefr 3y ago
> The real sci-fi moment will be when they get to the point they can treat in a day.
How do you imagine that would work?
Some closed-pipeline machine that lives in the hospital and automates sample → modified sample culture cycle?
Or something stranger, e.g. some kind of injectable (maybe prokaryotic?) cells that actively swim around looking for L-lymphocytes to vectorize through bacterial horizontal gene transfer — such that the whole process happens in vivo?
- puzzlingcaptcha 3y ago> Some closed-pipeline machine that lives in the hospital and automates sample → modified sample culture cycle? That's already a thing, for example Lonza's Cocoon platform or Miltenyi's Prodigy (both are often used for on-site manufacturing).
- panabee 3y agowould you mind sharing what you think are the largest bottlenecks to (1) 24-hr turnaround and (2) CAR-T therapy for < $10K?
- puzzlingcaptcha 3y agoI think that's near impossible to achieve with an autologous product. To meet those two goals I think you'd need to have an allogenic product manufactured and QCd in advance in a large batch, which you could thaw and infuse on demand. The problem with that approach is histocompatibility (HLA) matching, but several companies are working on that.
- panabee 3y agothanks for sharing. this is such an impactful space. hopefully someone one day can lower the cost to $10K or ideally $1K.