In my experience trying to send email from any address with something other than .com, .net, .org, and most 2-character country TLDs automatically counts agains

In my experience trying to send email from any address with something other than .com, .net, .org, and most 2-character country TLDs automatically counts against it by spam blockers to the point where users have to whitelist the address to see any emails (and even then they sometimes don't get them). Even newer three-character TLDs like .xyz are practically useless for sending emails.