Even without RSI, overwhelmingly the anecdotes about Dvorak are that it feels more comfortable. In terms of speed: I learned Dvorak, then went back to QWERTY.

Even without RSI, overwhelmingly the anecdotes about Dvorak are that it feels more comfortable. In terms of speed: I learned Dvorak, then went back to QWERTY. I returned to Dvorak a few years ago, and can now be faster with Dvorak than I was with QWERTY.